Ghrelin but not nesfatin-1 affects certain forms of learning and memory in both rats and mice
Ghrelin but not nesfatin-1 affects certain forms of learning and memory in both rats and mice
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Ghrelin 但不影响 nesfatin-1 影响大鼠和小鼠的某些形式的学习和记忆
DOI：
10.1016/j.brainres.2013.10.022
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发表时间：
2013-12
期刊：
影响因子：
2.9
通讯作者：
Yu Zhou
中科院分区：
文献类型：
--
作者：
Guo-Dong Li;Guo-Dong Li;Yu Zhou;Yu Zhou
Ghrelin和nesfatin-1是最近发现的两种肽激素，它们在人类和啮齿动物的食物摄入、体重控制和能量平衡中起着相反的作用。除了控制食欲的功能，越来越多的证据表明，胃饥饿素还影响中枢神经系统的多种高级活动，包括记忆和情绪。Nesfatin-1也广泛表达于下丘脑外脑区，包括海马和杏仁核。然而，巢脂素-1在这些重要大脑区域的可能作用在很大程度上是未知的。在本研究中，我们将ghrelin或nesfatin-1微量注入外侧杏仁核（LA）或海马背侧CA1区（CA1），并研究了这两种肽激素对认知和情感行为的直接影响。我们发现，在LA或CA1中微量注入ghrelin会干扰大鼠和小鼠的某些类型的学习和记忆，而nesfatin-1则没有影响。因此，我们的数据表明，尽管nesfatin-1在摄食控制中作为胃饥饿素的功能性拮抗剂起作用，但只有胃饥饿素影响学习和记忆。
Ghrelin and nesfatin-1 are two recently discovered peptide hormones that play opposite roles in the food intake, body-weight control and energy homeostasis in both human and rodents. Beyond its appetite-control function, increasing evidence has shown that ghrelin affects multiple advanced activities in the central nervous system, including memory and emotion. Nesfatin-1 was also widely expressed in extra-hypothalamic brain regions including hippocampus and amygdala. However, the possible actions of nesfatin-1 in those important brain regions are largely unknown. In this study, we micro-infused ghrelin or nesfatin-1 into the lateral amygdala (LA) or area CA1 of the dorsal hippocampus (CA1) and investigated the immediate effects of those two peptide hormones on cognitive and affective behaviors. We found that the micro infusion of ghrelin into the LA or the CA1 interfered with certain types of learning and memory in both rats and mice, while nesfatin-1 had no effect. Our data thus suggested that although nesfatin-1 works as a functional antagonist of ghrelin in the feeding control, only ghrelin affects learning and memory.
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影响因子：
2.7
作者：
Harms, Lauren R.;Eyles, Darryl W.;Burne, Thomas H. J.
通讯作者：
Burne, Thomas H. J.
DOI：
10.2174/187152710793361513
发表时间：
2010-11
期刊：
CNS & neurological disorders drug targets
影响因子：
--
作者：
Cong WN;Golden E;Pantaleo N;White CM;Maudsley S;Martin B
通讯作者：
Martin B
影响因子：
25
作者：
Zhou, Yu;Won, Jaejoon;Karlsson, Mikael Guzman;Zhou, Miou;Rogerson, Thomas;Balaji, Jayaprakash;Neve, Rachael;Poirazi, Panayiota;Silva, Alcino J.
通讯作者：
Silva, Alcino J.
DOI：
10.18632/aging.100207
发表时间：
2010-11
期刊：
Aging
影响因子：
--
作者：
Yoshida N;Maejima Y;Sedbazar U;Ando A;Kurita H;Damdindorj B;Takano E;Gantulga D;Iwasaki Y;Kurashina T;Onaka T;Dezaki K;Nakata M;Mori M;Yada T
通讯作者：
Yada T
影响因子：
1.7
作者：
M. Tanida;M. Mori
通讯作者：
M. Tanida;M. Mori