Fronto-subthalamic phase synchronization and cross-frequency coupling during conflict processing.
Fronto-subthalamic phase synchronization and cross-frequency coupling during conflict processing.
复制标题
冲突处理过程中的额-底丘脑相位同步和交叉频率耦合。
DOI：
10.1016/j.neuroimage.2021.118205
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发表时间：
2021-09
期刊：
影响因子：
5.7
通讯作者：
Chen R
中科院分区：
文献类型：
--
作者：
Zeng K;Drummond NM;Ghahremani A;Saha U;Kalia SK;Hodaie M;Lozano AM;Aron AR;Chen R
越来越多的证据表明，内侧前额叶皮层（mPFC）和丘脑下核（STN）在冲突处理中都起着至关重要的作用，但这两个结构如何协调它们的活动仍然知之甚少。在13例帕金森病患者执行Stroop任务时，我们使用深部脑刺激电极同时记录了其mPFC的脑电图和STN的局部场电位。与一致试验相比，mPFC和STN在不一致试验中都显示出显著的θ活动增加（2-8 Hz）。在不一致实验中，θ活动也显示出mPFC和STN之间的相位同步显著增加。此外，在不一致的实验中，伽玛振荡的幅度被STN上的θ活动的相位调制。反应速度快的不一致试验比反应速度慢的不一致试验的相振幅耦合（PAC）强得多。STN中theta-gamma PAC的升高提供了一种新的机制，通过这种机制，STN可以实现其所提议的“控制你的马”角色。mPFC-STN θ相位同步和STN θ - γ PAC同时出现，反映了冲突加工过程中额下丘脑通信的神经基础。更广泛地说，这可能是皮质-基底神经节回路中神经元相互作用的一般机制，通过远程、频内相位同步和局部跨频PAC的组合。
Growing evidence suggests that both the medial prefrontal cortex (mPFC) and the subthalamic nucleus (STN) play crucial roles in conflict processing, but how these two structures coordinate their activities remains poorly understood. We simultaneously recorded electroencephalogram from the mPFC and local field potentials from the STN using deep brain stimulation electrodes in 13 Parkinson’s disease patients while they performed a Stroop task. Both mPFC and STN showed significant increases in theta activities (2–8 Hz) in incongruent trials compared to the congruent trials. The theta activity in incongruent trials also demonstrated significantly increased phase synchronization between mPFC and STN. Furthermore, the amplitude of gamma oscillation was modulated by the phase of theta activity at the STN in incongruent trials. Such theta-gamma phase-amplitude coupling (PAC) was much stronger for incongruent trials with faster reaction times than those with slower reaction times. Elevated theta-gamma PAC in the STN provides a novel mechanism by which the STN may operationalize its proposed “hold-your-horses” role. The co-occurrence of mPFC-STN theta phase synchronization and STN theta-gamma PAC reflects a neural substrate for fronto-subthalamic communication during conflict processing. More broadly, it may be a general mechanism for neuronal interactions in the cortico-basal ganglia circuits via a combination of long-range, within-frequency phase synchronization and local cross-frequency PAC.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
11.2
作者：
Ghahremani A;Aron AR;Udupa K;Saha U;Reddy D;Hutchison WD;Kalia SK;Hodaie M;Lozano AM;Chen R
通讯作者：
Chen R
影响因子：
5.4
作者：
Chen, Wen-Hsiang;Strych, Ulrich;Bottazzi, Maria Elena
通讯作者：
Bottazzi, Maria Elena
DOI：
10.1016/j.cub.2016.01.051
发表时间：
2016-04-04
期刊：
Current biology : CB
影响因子：
--
作者：
Herz DM;Zavala BA;Bogacz R;Brown P
通讯作者：
Brown P
影响因子：
3.2
作者：
Cohen, Michael X.;Elger, Christian E.;Fell, Juergen
通讯作者：
Fell, Juergen