A New Era for Space Life Science: International Standards for Space Omics Processing.
A New Era for Space Life Science: International Standards for Space Omics Processing.
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DOI：
10.1016/j.patter.2020.100148
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发表时间：
2020-12-11
期刊：
影响因子：
--
通讯作者：
Muratani M
中科院分区：
文献类型：
--
作者：
Rutter L;Barker R;Bezdan D;Cope H;Costes SV;Degoricija L;Fisch KM;Gabitto MI;Gebre S;Giacomello S;Gilroy S;Green SJ;Mason CE;Reinsch SS;Szewczyk NJ;Taylor DM;Galazka JM;Herranz R;Muratani M
太空机构已经宣布了人类登月计划，为火星做准备。然而，空间环境带来的压力包括辐射、微重力和隔离。了解这些因素如何影响生物学对于安全有效的载人太空探索至关重要。有必要制定对策，使植物和微生物适应营养来源和生物再生生命支持，并限制病原体感染。世界各地的科学家正在对模式生物进行空间组学实验，最近还在对人类进行实验。从这些宝贵的数据集中最佳提取可操作的科学发现只有在改进标准化的情况下才能在集体层面上发生。为了解决这一缺陷，我们建立了ISSOP（空间组学处理国际标准），这是一个国际科学家联盟，旨在加强全球空间生物学家之间的标准准则。在这里，我们介绍了我们的联盟，并分享过去的经验教训和未来的挑战有关的航天组学。随着商业太空飞行的兴起和未来人类火星任务的发展，更广泛的健康人群将进入太空，时间更长，比以往任何时候都更容易暴露在环境压力下。在空间观察到许多不利的健康影响，包括骨脱矿和骨骼肌萎缩等。世界各地的科学家正在进行空间组学研究，以制定安全有效的载人航天任务的对策。然而，从这些数据中最佳地提取科学见解取决于改进标准化。作为回应，我们成立了ISSOP（空间组学处理国际标准），这是一个国际科学家联盟，旨在加强全球空间生物学家之间的指导方针。本文向来自许多领域的科学家和数据科学家介绍了空间组学的挑战和未来途径，并可作为空间生物学学科新成员的介绍性参考。人类进入太空的时间将比以往任何时候都更长，暴露在更高的环境压力下。在空间中观察到许多不利的健康影响，包括骨脱矿和骨骼肌萎缩。我们已成立了一个国际科学家联合会，旨在制定更好的空间生物学（特别是组学）数据标准化准则。从这些罕见的数据中最大限度地提取科学知识，可以导致安全和有效的载人航天任务所需的对策。
Space agencies have announced plans for human missions to the Moon to prepare for Mars. However, the space environment presents stressors that include radiation, microgravity, and isolation. Understanding how these factors affect biology is crucial for safe and effective crewed space exploration. There is a need to develop countermeasures, to adapt plants and microbes for nutrient sources and bioregenerative life support, and to limit pathogen infection. Scientists across the world are conducting space omics experiments on model organisms and, more recently, on humans. Optimal extraction of actionable scientific discoveries from these precious datasets will only occur at the collective level with improved standardization. To address this shortcoming, we established ISSOP (International Standards for Space Omics Processing), an international consortium of scientists who aim to enhance standard guidelines between space biologists at a global level. Here we introduce our consortium and share past lessons learned and future challenges related to spaceflight omics. With the rise of commercial spaceflight and prospective human missions to Mars, a wider health range of humans will enter space for longer spans and at higher exposure to environmental stressors than ever before. Numerous adverse health effects have been observed in space, including bone demineralization and skeletal muscle atrophy, among others. Scientists across the world are conducting space omics studies to develop countermeasures for safe and effective crewed space missions. However, optimal extraction of scientific insight from such data is contingent on improved standardization. In response, we founded ISSOP (International Standards for Space Omics Processing), an international consortium of scientists who aim to enhance guidelines between space biologists globally. This paper informs scientists and data scientists from many fields about the challenges and future avenues of space omics and can serve as an introductory reference for new members in the space biology discipline. Humans will be entering space for longer spans and at higher exposure to environmental stressors than ever before. Numerous adverse health effects have been observed in space, including bone demineralization and skeletal muscle atrophy. We have formed an international consortium of scientists who aim to develop better standardization guidelines of space biology (especially omics) data. Maximum extraction of scientific knowledge from these rare data can lead to countermeasures needed for safe and effective crewed space missions.
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影响因子：
1.2
作者：
Beheshti, Afshin;Shirazi-Fard, Yasaman;Costes, Sylvain V.
通讯作者：
Costes, Sylvain V.
影响因子：
3
作者：
Choi, Won-Gyu;Barker, Richard J.;Gilroy, Simon
通讯作者：
Gilroy, Simon
影响因子：
4.6
作者：
Beheshti A;Cekanaviciute E;Smith DJ;Costes SV
通讯作者：
Costes SV
影响因子：
46.9
作者：
Bernstein, Bradley E.;Stamatoyannopoulos, John A.;Costello, Joseph F.;Ren, Bing;Milosavljevic, Aleksandar;Meissner, Alexander;Kellis, Manolis;Marra, Marco A.;Beaudet, Arthur L.;Ecker, Joseph R.;Farnham, Peggy J.;Hirst, Martin;Lander, Eric S.;Mikkelsen, Tarjei S.;Thomson, James A.
通讯作者：
Thomson, James A.
影响因子：
16
作者：
Ainsztein AM;Brooks PJ;Dugan VG;Ganguly A;Guo M;Howcroft TK;Kelley CA;Kuo LS;Labosky PA;Lenzi R;McKie GA;Mohla S;Procaccini D;Reilly M;Satterlee JS;Srinivas PR;Church ES;Sutherland M;Tagle DA;Tucker JM;Venkatachalam S
通讯作者：
Venkatachalam S