Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations.
Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations.
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结肠粘膜细菌与血清类胡萝卜素浓度的个体间变异有关。
DOI：
10.1016/j.jand.2017.09.013
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发表时间：
2018-04
影响因子：
4.8
通讯作者：
Sen A
中科院分区：
文献类型：
--
作者：
Djuric Z;Bassis CM;Plegue MA;Ren J;Chan R;Sidahmed E;Turgeon DK;Ruffin MT 4th;Kato I;Sen A
相对较高的血清类胡萝卜素与慢性疾病风险降低有关，但血清类胡萝卜素浓度的个体间差异可以通过饮食来适度解释。结肠中的细菌群落可以通过完成植物细胞壁的消化和调节肠道通透性来促进类胡萝卜素的生物可及性。评估结肠细菌组成是否与血清和结肠类胡萝卜素浓度相关。该研究是一项随机饮食干预试验，对象是结肠癌风险增加的健康个体。在没有预先准备肠道的情况下，在干预前后6个月进行结肠粘膜活检。受试者于2007年7月至2010年11月从密歇根州安娜堡及附近地区招募。基线时88名参与者和6个月后82名参与者的活检数据可用。研究参与者被随机分为地中海式饮食和健康饮食两组，为期六个月。在基线时，研究参与者的活组织检查中的细菌群落在最高和最低的总血清类胡萝卜素百分比中有几个参数不同。线性判别分析效应大小（LEfSe）鉴定出11个与血清类胡萝卜素升高显著相关的操作分类单位。在线性回归分析中，在将体重指数、吸烟和饮食摄入量纳入模型后，其中三个因素占血清总类胡萝卜素浓度变化的12%。这些因素加在一起解释了36%的血清总类胡萝卜素浓度个体间差异。然而，在采用地中海饮食或健康饮食进行饮食干预后，结肠粘膜中的细菌群落对改变有抵抗力，每一种饮食都使水果和蔬菜摄入量增加一倍。结肠粘膜细菌群落与基线时血清类胡萝卜素浓度相关，但饮食干预没有明显改变。
Relatively high serum carotenoids are associated with reduced risks of chronic diseases, but inter-individual variability in serum carotenoid concentrations is modestly explained by diet. The bacterial community in the colon could contribute to the bio-accessibility of carotenoids by completing digestion of plant cells walls and by modulating intestinal permeability. To evaluate whether colonic bacterial composition is associated with serum and colon carotenoid concentrations. The study was a randomized dietary intervention trial in healthy individuals who were at increased risk of colon cancer. Colon mucosal biopsies were obtained before and after six months of intervention without prior preparation of the bowels. Participants were recruited from Ann Arbor, MI and nearby areas July 2007 to November 2010. Biopsy data was available from 88 participants at baseline and 82 participants after six months. Study participants were randomized to counseling for either a Mediterranean or a Healthy Eating diet for six months. At baseline, bacterial communities in biopsies from study participants in the highest versus the lowest tertile of total serum carotenoids differed by several parameters. Linear discriminant analysis effect size (LEfSe) identified 11 operational taxonomic units that were significantly associated with higher serum carotenoids. In linear regression analyses, three of these accounted for an additional 12% of the variance in serum total carotenoid concentrations after including body mass index, smoking, and dietary intakes in the model. These factors together explained 36% of the inter-individual variance in serum total carotenoid concentrations. The bacterial community in the colonic mucosa, however, was resistant to change after dietary intervention with either a Mediterranean or Healthy Eating diet, each of which doubled fruit and vegetable intakes. The colonic mucosal bacterial community was associated with serum carotenoid concentrations at baseline but was not appreciably changed by dietary intervention.
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影响因子：
4.7
作者：
Kabat, G. C.;Kim, M. Y.;Rohan, T. E.
通讯作者：
Rohan, T. E.
影响因子：
4.7
作者：
Galan, P;Viteri, FE;Hercberg, S
通讯作者：
Hercberg, S
影响因子：
4.7
作者：
Al-Delaimy, WK;Ferrari, P;Riboli, E
通讯作者：
Riboli, E
DOI：
10.1152/ajpgi.00044.2014
发表时间：
2014-07-01
影响因子：
4.5
作者：
Greiner, Allen K.;Papineni, Rao V. L.;Umar, Shahid
通讯作者：
Umar, Shahid
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y