Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.
Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.
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DOI：
10.1002/nbm.4518
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发表时间：
2021-07
影响因子：
2.9
通讯作者：
Nguyen KL
中科院分区：
文献类型：
--
作者：
Colbert CM;Le AH;Shao J;Currier JW;Ajijola OA;Hu P;Nguyen KL
心肌T1反应性，定义为静息和血管扩张剂诱导的应激之间T1的相对变化，已被提议作为组织灌注的磁共振成像（MRI）生物标志物。我们假设，超顺磁性氧化铁纳米粒子，ferumoxytol，敏感T1心肌内血管室的变化，并提高T1反应的灵敏度和特异性作为组织灌注的成像生物标志物。我们的目的是评估猪心肌灌注不足模型中ferumoxytol增强（FE）心肌T1反应性的诊断性能。我们通过将3D打印的冠状动脉内狭窄植入物经皮、经导管部署到左前降支冠状动脉中，在13只猪中诱导急性心肌灌注不足。我们使用5（3）3（3）3 MOLLI和SASHA T1标测序列在临床3.0 T磁体上进行了天然和FE腺苷应力测试，其中bSSFP读数。使用常规MOLLI和瞬时信号丢失（InSiL）T1拟合算法拟合MOLLI T1图。无论MOLLI或SASHA脉冲序列或T1拟合算法，ferumoxytol对比度增加了T1反应性的动态范围在远程和缺血心肌区域。相对于远端心肌，InSiL-MOLLI、MOLLI和SASHA在缺血心肌中的天然和FE T1反应性减弱（p<0.05）。InSiL-MOLLI推导的FE T1反应性阈值为-4.65%，预测局部室壁运动异常的敏感性为73.3%，特异性为96.2（AUC 0.915，95% CI 0.786-0.979），而SASHA衍生的FE T1反应性阈值为-5.25%，灵敏度为75.0%，特异性为95.2%（AUC 0.905，95% CI 0.751-0.979）。Ferumoxytol显着增加T1反应性的动态范围，作为衡量心肌灌注不足的血管舒张应力T1映射研究。FE T1反应性图可用于定量区分猪急性心肌低灌注模型中的缺血心肌和远隔心肌，具有高度特异性。
Myocardial T1 reactivity, defined as the relative change in T1 between rest and vasodilator-induced stress, has been proposed as a magnetic resonance imaging (MRI) biomarker of tissue perfusion. We hypothesize that the superparamagnetic iron-oxide nanoparticle, ferumoxytol, sensitizes T1 to changes in the intramyocardial vascular compartment and improves the sensitivity and specificity of T1 reactivity as an imaging biomarker of tissue perfusion. We aim to assess the diagnostic performance of ferumoxytol-enhanced (FE) myocardial T1 reactivity in swine models of myocardial hypoperfusion. We induced acute myocardial hypoperfusion in 13 swine via percutaneous, transcatheter deployment of a 3D printed intracoronary stenosis implant into the left anterior descending coronary artery. We performed native and FE adenosine stress testing using 5(3)3(3)3 MOLLI and SASHA T1 mapping sequences with bSSFP readout on a clinical 3.0 T magnet. MOLLI T1 maps were fitted using both the conventional MOLLI and the Instantaneous Signal Loss (InSiL) T1 fitting algorithms. Regardless of MOLLI or SASHA pulse sequence or T1 fitting algorithm, ferumoxytol contrast increased the dynamic range of T1 reactivity in both remote and ischemic myocardial regions. Relative to remote myocardium, native and FE T1 reactivity were blunted in ischemic myocardium (p<0.05) with InSiL-MOLLI, MOLLI, and SASHA. An InSiL-MOLLI-derived FE T1 reactivity threshold of -4.65% had 73.3% sensitivity and 96.2% specificity for prediction of regional wall motion abnormalities (AUC 0.915, 95% CI 0.786–0.979), whereas a SASHA-derived FE T1 reactivity threshold of −5.25% had a 75.0% sensitivity and 95.2% specificity (AUC 0.905, 95% CI 0.751–0.979). Ferumoxytol significantly increased the dynamic range of T1 reactivity as a measure of myocardial hypoperfusion in vasodilator stress T1 mapping studies. FE T1 reactivity maps can be used to quantitatively distinguish ischemic and remote myocardium with high specificity in swine models of acute myocardial hypoperfusion.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
DOI：
10.3791/60729
发表时间：
2020-02-18
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Hollowed JJ;Colbert CM;Currier JW;Nguyen KL
通讯作者：
Nguyen KL
心肌血容量和流量在冠状动脉疾病中的作用：静息和充血期间的实验性 MRI 研究。
影响因子：
5.9
作者：
McCommis, Kyle S.;Goldstein, Thomas A.;Abendschein, Dana R.;Misselwitz, Bernd;Pilgram, Thomas;Gropler, Robert J.;Zheng, Jie
通讯作者：
Zheng, Jie
影响因子：
3.3
作者：
Knobloch, Gesine;Colgan, Timothy;Nagle, Scott K.
通讯作者：
Nagle, Scott K.
影响因子：
5
作者：
Bohnen, Sebastian;Pruessner, Lennard;Muellerleile, Kai
通讯作者：
Muellerleile, Kai