Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.
Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.
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黑腹果蝇毛翼抑制基因和 mdg4 基因修饰基因突变之间的相互作用影响吉普赛诱导突变的表型。
作者：
P. Georgiev;Marina Kozycina
Hairy-wing [su(Hw)] 蛋白的抑制子通过抑制相对于 su(Hw) 结合区位置位于启动子远端的转录增强子的功能来介导 gypsy 逆转录转座子的诱变作用。第二个基因（mdg4 的修饰基因）的突变也会影响吉普赛人诱发的表型。 mod(mdg4)1u1 突变的两个主要影响可以区分：su(Hw) 结合区对绝缘的干扰以及不依赖于 su(Hw) 结合区位置的基因表达的直接抑制。 mod(mdg4)1u1 突变部分抑制 ct6、scD1 和 Hw1 突变，可能是通过干扰 su(Hw) 结合区的绝缘效应。 mod(mdg4)1u1 的第二个效应的一个例子是与 y2 等位基因结合的黄色表达的完全失活。对 mod(mdg4)1u1 和不同 su(Hw) 突变组合的果蝇的表型分析，或带有 su(Hw) 蛋白酸性结构域缺失的结构的表型分析表明，羧基末端酸性结构域对于直接抑制鬃毛中的黄色转录非常重要，而氨基末端酸性结构域对于绝缘更为重要。
The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers located distally from the promoter with respect to the position of the su(Hw)-binding region. Mutations in a second gene, modifier of mdg4, also affect the gypsy-induced phenotype. Two major effects of the mod(mdg4)1u1 mutation can be distinguished: the interference with insulation by the su(Hw)-binding region and direct inhibition of gene expression that is not dependent on the su(Hw)-binding region position. The mod(mdg4)1u1 mutation partially suppresses ct6, scD1 and Hw1 mutations, possibly by interfering with the insulation effect of the su(Hw)-binding region. An example of the second effect of mod(mdg4)1u1 is a complete inactivation of yellow expression in combination with the y2 allele. Phenotypic analyses of flies with combinations of mod(mdg4)1u1 and different su(Hw) mutations, or with constructions carrying deletions of the acidic domains of the su(Hw) protein, suggest that the carboxy-terminal acidic domain is important for direct inhibition of yellow transcription in bristles, while the amino-terminal acidic domain is more essential for insulation.
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影响因子：
10.5
作者：
GEYER, PK;CORCES, VG
通讯作者：
CORCES, VG
果蝇毛翼蛋白的抑制因子与吉普赛反转录转座子的特定序列结合。
影响因子：
10.5
作者：
Spana,C;Harrison,DA;Corces,VG
通讯作者：
Corces,VG
影响因子：
3.3
作者：
H. Robertson;C. Preston;R. Phillis;D. Johnson-Schlitz;Wendy K. Benz;W. Engels
通讯作者：
H. Robertson;C. Preston;R. Phillis;D. Johnson-Schlitz;Wendy K. Benz;W. Engels
逆转录转座子与宿主基因组的相互作用：以果蝇吉普赛元素为例。
DOI：
10.1016/0168-9525(91)90277-w
发表时间：
1991
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Corces,VG;Geyer,PK
通讯作者：
Geyer,PK
DNA 弯曲是果蝇锌指蛋白结合特异性的决定因素。
影响因子：
10.5
作者：
Spana,C;Corces,VG
通讯作者：
Corces,VG