The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion.
The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion.
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DOI：
10.1055/s-0032-1314949
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发表时间：
2012-06
期刊：
影响因子：
2.7
通讯作者：
Towler MJ
中科院分区：
文献类型：
--
作者：
Weathers PJ;Towler MJ
许多黄酮类化合物，包括来自青蒿的蓖麻素和青蒿素，与青蒿素显示出对抗恶性疟原虫的协同作用，但尚不清楚黄酮类化合物是否也被提取到该植物的茶汤中。据报道，使用对青蒿素提取非常有效的茶浸液制备方案，我们测量了牡蛎碱和青蒿素的提取情况。输注液中牡荆素的回收率仅为 1.8%，而青蒿素则检测不到。室温保存 24 小时后，蓖麻素产量下降了 40%。这些结果表明，虽然该植物的茶浸液可以提取青蒿素，但多甲氧基化黄酮类化合物、牡蛎碱和青蒿素的提取效果较差，并且在室温下储存时会损失，因此，茶浸液似乎失去了协同价值。
A number of flavonoids including casticin and artemetin from Artemisia annua have shown synergism with artemisinin against Plasmodium falciparum, but it is unclear if flavonoids are also extracted into a tea infusion of the plant. Using a tea infusion preparation protocol that was reported to be highly effective for artemisinin extraction, we measured casticin and artemetin extraction. There was only a 1.8% recovery of casticin in the infusion while artemetin was undetectable. After 24 hr storage at room temperature, casticin yield declined by 40%. These results show that although a tea infusion of the plant may extract artemisinin, the polymethoxylated flavonoids, casticin and artemetin, are poorly extracted and lost with storage at room temperature and thus, the tea infusion appears to lose synergistic value.
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影响因子：
2
作者：
Ferreira, Jorge F. S.;Peaden, Paul;Keiser, Jennifer
通讯作者：
Keiser, Jennifer
DOI：
10.3390/molecules15053135
发表时间：
2010-04-29
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Ferreira JF;Luthria DL;Sasaki T;Heyerick A
通讯作者：
Heyerick A
DOI：
10.1007/s11101-010-9166-0
发表时间：
2011-06
期刊：
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
影响因子：
--
作者：
Weathers PJ;Arsenault PR;Covello PS;McMickle A;Teoh KH;Reed DW
通讯作者：
Reed DW
影响因子：
6.2
作者：
LIU, KCSC;YANG, SL;PHILLIPSON, JD
通讯作者：
PHILLIPSON, JD
影响因子：
2.7
作者：
van der Kooy, Frank;Verpoorte, Robert
通讯作者：
Verpoorte, Robert