Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction.
Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction.
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DOI：
10.1016/j.neuroimage.2012.12.015
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发表时间：
2013-04-01
期刊：
影响因子：
5.7
通讯作者：
Bifone A
中科院分区：
文献类型：
--
作者：
Gozzi A;Agosta F;Massi M;Ciccocioppo R;Bifone A
酒精滥用与额叶皮质体积和边缘代谢的长期减少有关。然而，酒精研究中一个悬而未决的问题是，这些变化是长期饮酒的唯一结果，还是反映了乙醇成瘾的生物倾向的遗传因素。酒精依赖的遗传易感性动物模型可以用来研究先天大脑异常在酒精中毒病因学中的作用。在这里，我们使用磁共振成像(MRI)对马奇吉安撒丁岛(MSP)酒精偏好的大鼠进行评估，以评估是否存在遗传性的大脑结构或功能改变。对22只单纯酒精MSP大鼠和26只正常对照大鼠进行基础脑血容量(BCBV)标测、灰质体素形态计量学(VBM)和脑白质各向异性区块空间统计学标测。MSP大鼠大脑皮质-边缘和丘脑局灶区的bCBV显著降低，同时丘脑、腹侧被盖区、岛叶和扣带回的灰质体积减少。两组之间的分数各向异性没有统计学上的显著差异。这些发现突显了酒精天真MSP大鼠先天灰质和代谢异常的存在，其定位和体征与戒酒者和酒精依赖高危对象的定位和体征非常相似。总之，这些结果表明，可遗传的神经功能大脑改变在乙醇成瘾的生物倾向中发挥了重要作用，并支持使用先进的成像方法来描述药物成瘾易感性的回路决定因素。
Alcohol abuse is associated with long-term reductions in fronto-cortical volume and limbic metabolism. However, an unanswered question in alcohol research is whether these alterations are the sole consequence of chronic alcohol use, or contain heritable contributions reflecting biological propensity toward ethanol addiction. Animal models of genetic predisposition to alcohol dependence can be used to investigate the role of inborn brain abnormalities in the aetiology of alcoholism. Here we used magnetic resonance imaging (MRI) in e Marchigian Sardinian (msP) alcohol-preferring rats to assess the presence of inherited structural or functional brain alterations. Alcohol-naïve msP (N=22) and control rats (N=26) were subjected to basal cerebral blood volume (bCBV) mapping followed by voxel-based morphometry (VBM) of gray matter and tract-based spatial statistics mapping of white matter fractional anisotropy. msP rats exhibited significantly reduced bCBV, an established marker of resting brain function, in focal cortico-limbic and thalamic areas, together with reduced gray matter volume in the thalamus, ventral tegmental area, insular and cingulate cortex. No statistically significant differences in fractional anisotropy were observed between groups. These findings highlight the presence of inborn gray matter and metabolic abnormalities in alcohol-naïve msP rats, the localization and sign of which are remarkably similar to those mapped in abstinent alcoholics and subjects at high risk for alcohol dependence. Collectively, these results point for a significant role of heritable neurofunctional brain alterations in biological propensity toward ethanol addiction, and support the translational use of advanced imaging methods to describe the circuital determinants of vulnerability to drug addiction.
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影响因子：
5.7
作者：
Fein, George;Landman, Bennett;Moon, Kirk
通讯作者：
Moon, Kirk
DOI：
10.1097/00000374-200204000-00017
发表时间：
2002-04-01
影响因子：
3.2
作者：
Fein, G;Di Sclafani, V;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ
影响因子：
3.4
作者：
Ciccocioppo, R;Panocka, I;Massi, M
通讯作者：
Massi, M
影响因子：
3.6
作者：
BAKER, R;MELCHIOR, C;DEITRICH, R
通讯作者：
DEITRICH, R
影响因子：
2.3
作者：
Cardenas, VA;Studholme, C;Weiner, MW
通讯作者：
Weiner, MW