Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation.
Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation.
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DOI：
10.1016/j.bpsc.2017.08.008
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Sheridan MA
中科院分区：
文献类型：
--
作者：
Miller AB;McLaughlin KA;Busso DS;Brueck S;Peverill M;Sheridan MA
与自杀意念（SI）风险相关的神经相关性研究一直有限，特别是在一个日益增加的风险群体-青少年。先前对青少年的研究表明，不良的情绪调节技能与SI有关，但这些研究以前没有研究过那些有和没有SI历史的人之间的情绪调节的神经激活。在这里，我们研究是否SI与神经反应在情绪调节功能磁共振成像任务在一组青少年（N=49）年龄在13至20岁（M = 16.95）。虽然有和没有SI的年轻人在自我报告的负面图片的情绪反应没有差异，但与被动观看负面图片的试验相比，SI的年轻人在试图调节情绪反应的试验中比没有SI的年轻人激活了背外侧前额叶皮层（dlPFC）。相反，在被动观看负面刺激，青年SI激活dlPFC，颞顶交界处，小脑小于同龄对照组。这些发现对抑郁和逆境暴露的控制是稳健的，并且与SI青年扰乱情绪调节的想法一致，这可能与自上而下控制区域的招募差异有关。相比之下，没有SI的年轻人激活了与情绪调节有关的区域，即使没有努力控制他们的情绪反应。这是第一个研究情绪调节过程中的神经功能，作为青少年SI风险的潜在神经相关性。
Research on the neural correlates associated with risk for suicidal ideation (SI) has been limited, particularly in one increasingly at risk group—adolescents. Previous research with adolescents indicates that poor emotion regulation skills are linked with SI, but these studies have not previously examined neural activation in service of emotion regulation between those with and without SI histories. Here we examine whether SI is associated with neural responses during an emotion regulation fMRI task in a group of adolescents (N=49) ages 13 to 20 years old (M = 16.95). While there were no differences between youth with and without SI in self-reported emotional responses to negative pictures, youth with SI activated the dorsolateral prefrontal cortex (dlPFC) more than youth without SI on trials where they attempted to regulate their emotional responses compared to trials where they passively viewed negative pictures. In contrast, during passive viewing of negative stimuli, youth with SI activated the dlPFC, temporoparietal junction, and cerebellum less than same age controls. These findings were robust to controls for depression and adversity exposure and are consistent with the idea that youth with SI have disrupted emotion regulation, potentially related to differences in recruitment of top-down control regions. In contrast, youth without SI activated regions implicated in emotion regulation even when not directed to effortfully control their emotional response. This is the first study to examine neural function during emotion regulation as a potential neural correlate of risk for SI in adolescents.
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