Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization.
Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization.
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DOI：
10.1016/j.drugalcdep.2021.109198
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发表时间：
2022-01-01
影响因子：
4.2
通讯作者：
Kerns JG
中科院分区：
文献类型：
--
作者：
Hua JPY;de Lange SC;van den Heuvel MP;Boness CL;Trela CJ;McDowell YE;Merrill AM;Piasecki TM;Sher KJ;Kerns JG
成年初显期是一个关键的神经发育阶段，在此期间饮酒始终与大脑解剖结构和白色物质完整性的异常和损伤有关。然而，目前尚不清楚酒精使用如何与大脑的结构组织（即，解剖区域之间的白色物质连接）。最近的连接体研究集中在富人俱乐部区域，这是一组高度互连的枢纽，在大脑通信和全球网络组织中至关重要，并且不成比例地容易受到侮辱。我们第一次研究了酒精使用与新兴成年人（N=66）的结构丰富俱乐部和连接体组织的关系。终生饮酒量和当前每月饮酒量的增加与富人俱乐部组织性的降低（rs=-0.38，ps<.003）和富人俱乐部连通性的降低（rs<-0.34，ps<.007）显著相关。此外，富人俱乐部的连通性与酒精使用的负相关性比非富人俱乐部地区的连通性更显著（ps<.035）。检查整体结构组织，更大的终身饮料和当前每月饮料与较低的网络密度显著相关（即，较低的网络弹性; rs<−.36，ps=.004）。此外，更大的终身饮酒量和当前每月饮酒量与更高的网络隔离显著相关（即，网络分成子网络的趋势; rs> 0.33，ps<0.008）。饮酒与网络整合没有显著相关（即，网络在大脑中组合信息的效率; ps> 0.064）。研究结果提供了新的证据表明，饮酒与富人俱乐部连通性降低和结构网络紊乱有关。鉴于两者在全球大脑交流中都至关重要，这些结果突出了研究酒精使用和成年后大脑关系的重要性。
Emerging adulthood is a critical neurodevelopmental stage, with alcohol use during this period consistently associated with brain abnormalities and damage in anatomical structure and white matter integrity. However, it is less clear how alcohol use is associated with the brain’s structural organization (i.e., white matter connections between anatomical regions). Recent connectome research has focused on rich-club regions, a collection of highly-interconnected hubs that are critical in brain communication and global network organization and disproportionately vulnerable to insults. For the first time, we examined alcohol use associations with structural rich-club and connectome organization in emerging adults (N=66). Greater lifetime drinks and current monthly drinks were significantly associated with lower rich-club organization (rs=−.38, ps<.003) and lower rich-club connectivity (rs<−.34, ps<.007). Additionally, rich-club connectivity was significantly more negatively correlated with alcohol use than connectivity among non-rich-club regions (ps<.035). Examining overall structural organization, greater lifetime drinks and current monthly drinks were significantly associated with lower network density (i.e., lower network resilience; rs<−.36, ps=.004). Additionally, greater lifetime drinks and current monthly drinks were significantly associated with higher network segregation (i.e., network’s tendency to divide into subnetworks; rs>.33, ps<.008). Alcohol use was not significantly associated with network integration (i.e., network’s efficiency in combining information across the brain; ps>.064). Results provide novel evidence that alcohol use is associated with decreased rich-club connectivity and structural network disorganization. Given that both are critical in global brain communication, these results highlight the importance of examining alcohol use and brain relationships in emerging adulthood.
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DOI：
10.1016/j.bpsc.2018.02.006
发表时间：
2018-07-01
影响因子：
5.9
作者：
Meda, Shashwath A.;Hawkins, Keith A.;Pearlson, Godfrey D.
通讯作者：
Pearlson, Godfrey D.
前瞻性研究检查了极端饮酒对新兴成年人大脑结构的影响。
DOI：
10.1111/acer.14446
发表时间：
2020-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Hua JPY;Sher KJ;Boness CL;Trela CJ;McDowell YE;Merrill AM;Piasecki TM;Kerns JG
通讯作者：
Kerns JG
影响因子：
4.8
作者：
Kuceyeski, Amy;Meyerhoff, Dieter J.;Durazzo, Timothy C.;Raj, Ashish
通讯作者：
Raj, Ashish
影响因子：
29.9
作者：
de Lange, Siemon C.;Scholtens, Lianne H.;van den Heuvel, Martijn P.
通讯作者：
van den Heuvel, Martijn P.
DOI：
10.1073/pnas.1009073107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Hagmann, P.;Sporns, O.;Grant, P. E.
通讯作者：
Grant, P. E.