Systematic evaluation of nanomaterial toxicity: utility of standardized materials and rapid assays.
Systematic evaluation of nanomaterial toxicity: utility of standardized materials and rapid assays.
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DOI：
10.1021/nn200546k
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发表时间：
2011-06-28
期刊：
影响因子：
17.1
通讯作者：
Tanguay RL
中科院分区：
文献类型：
--
作者：
Harper SL;Carriere JL;Miller JM;Hutchison JE;Maddux BL;Tanguay RL
优化纳米材料的性能和安全性的挑战取决于我们解决哪些结构特征导致所需特性的能力。由于缺乏纳米材料特性、纯度未知和/或生物环境对纳米材料的改变，很难从许多纳米材料研究中得出有关生物影响的有意义的结论。为了研究核心尺寸，表面化学和电荷对纳米材料毒性的相对影响，我们测试了暴露于9种结构多样，精密设计的高纯度和已知组成的金纳米颗粒（AuNPs）基质的整个动物的生物反应。矩阵的成员包括三个核心大小和四个独特的表面涂层，包括正电荷和负电荷的头基。死亡率，畸形，摄取和消除的金纳米粒子都依赖于这些参数，显示需要严格控制的实验设计和纳米材料表征。本文介绍的结果说明了一个综合的方法，以确定设计规则，最大限度地减少潜在的危险的价值。
The challenge of optimizing both performance and safety in nanomaterials hinges on our ability to resolve which structural features lead to desired properties. It has been difficult to draw meaningful conclusions about biological impacts from many studies of nanomaterials due to the lack of nanomaterial characterization, unknown purity, and/or alteration of the nanomaterials by the biological environment. To investigate the relative influence of core size, surface chemistry, and charge on nanomaterial toxicity, we tested the biological response of whole animals exposed to a matrix of nine structurally diverse, precision-engineered gold nanoparticles (AuNPs) of high purity and known composition. Members of the matrix include three core sizes and four unique surface coatings that include positively and negatively charged headgroups. Mortality, malformations, uptake, and elimination of AuNPs were all dependent on these parameters, showing the need for tightly controlled experimental design and nanomaterial characterization. Results presented herein illustrate the value of an integrated approach to identify design rules that minimize potential hazard.
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