Important role of CCR2 in a murine model of coronary vasculitis.
Important role of CCR2 in a murine model of coronary vasculitis.
复制标题
DOI：
10.1186/1471-2172-13-56
复制
发表时间：
2012-10-17
期刊：
影响因子：
3
通讯作者：
Ahuja SS
中科院分区：
文献类型：
--
作者：
Martinez HG;Quinones MP;Jimenez F;Estrada C;Clark KM;Suzuki K;Miura N;Ohno N;Ahuja SK;Ahuja SS
Chemokines and their receptors play a role in the innate immune response as well as in the disruption of the balance between pro-inflammatory Th17 cells and regulatory T cells (Treg), underlying the pathogenesis of coronary vasculitis in Kawasaki disease (KD). Here we show that genetic inactivation of chemokine receptor (CCR)-2 is protective against the induction of aortic and coronary vasculitis following injection of Candida albicans water-soluble cell wall extracts (CAWS). Mechanistically, both T and B cells were required for the induction of vasculitis, a role that was directly modulated by CCR2. CAWS administration promoted mobilization of CCR2-dependent inflammatory monocytes (iMo) from the bone marrow (BM) to the periphery as well as production of IL-6. IL-6 was likely to contribute to the depletion of Treg and expansion of Th17 cells in CAWS-injected Ccr2+/+ mice, processes that were ameliorated following the genetic inactivation of CCR2. Collectively, our findings provide novel insights into the role of CCR2 in the pathogenesis of vasculitis as seen in KD and highlight novel therapeutic targets, specifically for individuals resistant to first-line treatments.
登录
查看更多内容
影响因子：
5.1
作者：
Furuno, K;Yuge, T;Hara, T
通讯作者：
Hara, T
影响因子：
3.6
作者：
Jibiki, T;Terai, M;Kohno, Y
通讯作者：
Kohno, Y
在动脉粥样硬化之前和开发过程中淋巴细胞募集到主动脉壁是部分依赖性L-选择蛋白。
DOI：
10.1084/jem.20052205
发表时间：
2006-05-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.2
作者：
Koga, M;Ishihara, T;Furukawa, S
通讯作者：
Furukawa, S
影响因子：
4.6
作者：
Katayama, K;Matsubara, T;Furukawa, S
通讯作者：
Furukawa, S