Arbovirus circulation, epidemiology and spatiotemporal distribution in Uganda.
Arbovirus circulation, epidemiology and spatiotemporal distribution in Uganda.
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DOI：
10.1016/j.ijregi.2023.01.013
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Lutwama, Julius J.
中科院分区：
文献类型：
--
作者：
Byaruhanga, Timothy;Kayiwa, John T.;Nankya, Annet M.;Ataliba, Irene J.;McClure, C. Patrick;Ball, Jonathan K.;Lutwama, Julius J.
乌干达虫媒病毒免疫球蛋白M血清阳性率估计为9.5%黄热病病毒是最流行的虫媒病毒时空分析确定了4个虫媒病毒风险较高的地区在5−-14岁年龄组中虫媒病毒病负担很高需要大规模黄热病疫苗接种和持续虫媒病毒监测虫媒病毒在乌干达流行；然而，对其流行病学、季节性和时空分布知之甚少。我们的研究试图从急性临床表现中提供虫媒病毒暴发的信息。回顾分析2016年−19年从哨点采集的虫媒病毒样本的免疫球蛋白M和确认性空斑减少中和试验结果。用SATScan和SPSS软件对人口学数据进行分析，以确定虫媒病毒的流行病学和时空分布。虫媒病毒活动在3月−5月雨季持续达到顶峰。总体而言，虫媒病毒血清阳性率为9.5%。在137例IgM阳性患者中，52.6%的人被确诊，其中73.6%的病例发生在乌干达中部，黄热病病毒的流行率最高(27.8%)。5-−-14年龄组感染虫媒病毒的概率是5-14岁组的4倍，p=0.003，4.1(95%CI 1.3−12.3)。在户外作业工人中观察到显著的虫媒病毒活动(p=0.05)。时空分析表明，在所分析的85个地区中，有23个地区存在虫媒病毒活动。我们的研究表明，虫媒病毒的活动在3月−5月的雨季达到顶峰，并突显了大规模接种YFV疫苗的必要性，以减少在该地区传播的虫媒病毒的临床负担。
Immunoglobulin M seroprevalence of arboviruses in Uganda was estimated at 9.5% Yellow fever virus was the most prevalent arbovirus Spatiotemporal analysis identified four districts with high arbovirus risk There is a high burden of arboviral disease among the 5−14 years age group Mass yellow fever vaccination and continuous arbovirus surveillance are needed Arboviruses are endemic in Uganda; however, little is known about their epidemiology, seasonality and spatiotemporal distribution. Our study sought to provide information on arbovirus outbreaks from acute clinical presentations. Immunoglobulin M (IgM) and confirmatory Plaque Reduction Neutralisation Test (PRNT) results for arbovirus diagnosis of samples collected from patients attending sentinel sites from 2016−19 were analysed retrospectively. Demographic data were analysed with SaTScan and SPSS software to determine the epidemiology and spatiotemporal distribution of arboviruses. Arbovirus activity peaked consistently during March−May rainy seasons. Overall, arbovirus seroprevalence was 9.5%. Of 137 IgM positives, 52.6% were confirmed by PRNT, of which 73.6% cases were observed in central Uganda with Yellow Fever Virus had the highest prevalence (27.8%). The 5−14 age group were four times more likely to be infected with an arbovirus p=0.003, 4.1 (95% CI 1.3−12.3). Significant arboviral activity was observed among outdoor workers(p=0.05) . Spatiotemporal analysis indicated arboviral activity in 23 of the 85 districts analysed.. Our study shows that arbovirus activity peaks during the March−May rainy season and highlights the need for YFV mass vaccination to reduce the clinical burden of arboviruses transmitted within the region.
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影响因子：
0.8
作者：
Kulldorff, M
通讯作者：
Kulldorff, M
影响因子：
12.7
作者：
Kulldorff, M;Athas, WF;Key, CR
通讯作者：
Key, CR
影响因子：
4.2
作者：
Twinomuhangi, Revocatus;Sseviiri, Hakimu;Kato, Arthur Martin
通讯作者：
Kato, Arthur Martin
DOI：
10.4269/ajtmh.20-0408
发表时间：
2020-12
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Carrera JP;Cucunubá ZM;Neira K;Lambert B;Pittí Y;Liscano J;Garzón JL;Beltran D;Collado-Mariscal L;Saenz L;Sosa N;Rodriguez-Guzman LD;González P;Lescano AG;Pereyra-Elías R;Valderrama A;Weaver SC;Vittor AY;Armién B;Pascale JM;Donnelly CA
通讯作者：
Donnelly CA
影响因子：
3.8
作者：
Kayiwa, John Timothy;Nankya, Annet Martha;Lutwama, Julius Julian
通讯作者：
Lutwama, Julius Julian