Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.
Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.
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DOI：
10.3390/nu13082768
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发表时间：
2021-08-12
期刊：
影响因子：
5.9
通讯作者：
El-Bacha T
中科院分区：
文献类型：
--
作者：
Belcastro L;Ferreira CS;Saraiva MA;Mucci DB;Murgia A;Lai C;Vigor C;Oger C;Galano JM;Pinto GDA;Griffin JL;Torres AG;Durand T;Burton GJ;Sardinha FLC;El-Bacha T
发达国家和发展中国家育龄妇女肥胖率的上升可能会传播对代谢健康产生有害影响的代际循环。母亲肥胖会扰乱胎盘的脂质代谢，这可能会影响后代的终生健康。在这里，我们研究了孕前肥胖作为唯一妊娠并发症的妇女的胎盘脂质代谢，并将其与瘦身妇女的胎盘反应进行了比较。开放档案和靶向脂质组学分别用于评估胎盘脂质和氧化产物二十二碳六烯酸(DHA)和花生四烯酸(AA)、神经前列腺素和异前列腺素。尽管总体上没有脂肪积聚的迹象，但肥胖女性胎盘中的DHA和AA水平分别是瘦女性的2.2倍和2.5倍。此外，肥胖组中DHA来源的神经前列腺素增加了2倍，AA来源的异前列腺素增加了1.7倍。这些变化与胎盘FABP1蛋白减少70%有关。多变量分析表明，神经前列腺素和异前列腺素与母体和胎盘炎症以及新生儿体重有关。这些结果可能会揭示与孕前肥胖母亲胎盘脂肪酸代谢改变相关的分子机制，使这些氧化脂肪酸成为胎盘功能的新介质。
The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by maternal obesity, which possibly affects the life-long health of the offspring. Here, we investigated placental lipid metabolism in women with pre-gestational obesity as a sole pregnancy complication and compared it to placental responses of lean women. Open profile and targeted lipidomics were used to assess placental lipids and oxidised products of docosahexaenoic (DHA) and arachidonic acid (AA), respectively, neuroprostanes and isoprostanes. Despite no overall signs of lipid accumulation, DHA and AA levels in placentas from obese women were, respectively, 2.2 and 2.5 times higher than those from lean women. Additionally, a 2-fold increase in DHA-derived neuroprostanes and a 1.7-fold increase in AA-derived isoprostanes were seen in the obese group. These changes correlated with a 70% decrease in placental FABP1 protein. Multivariate analyses suggested that neuroprostanes and isoprostanes are associated with maternal and placental inflammation and with birth weight. These results might shed light on the molecular mechanisms associated with altered placental fatty acid metabolism in maternal pre-gestational obesity, placing these oxidised fatty acids as novel mediators of placental function.
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影响因子：
3.8
作者：
Alvarado, Fernanda L.;Calabuig-Navarro, Virtu;O'Tierney-Ginn, Perrie
通讯作者：
O'Tierney-Ginn, Perrie
影响因子：
6.3
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Gazquez，A.;Prieto-Sanchez，M. T.;Larque，E.
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5.5
作者：
Gazquez, Antonio;Prieto-Sanchez, Maria T.;Larque, Elvira
通讯作者：
Larque, Elvira
影响因子：
5.9
作者：
Easton ZJW;Regnault TRH
通讯作者：
Regnault TRH
影响因子：
4.8
作者：
Cook, Damon B.;McLucas, Brian C.;Sebata, Thao H.
通讯作者：
Sebata, Thao H.