Human parainfluenza 2 & 4: Clinical and genetic epidemiology in the UK, 2013-2017, reveals distinct disease features and co-circulating genomic subtypes.
Human parainfluenza 2 & 4: Clinical and genetic epidemiology in the UK, 2013-2017, reveals distinct disease features and co-circulating genomic subtypes.
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DOI：
10.1111/irv.13012
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发表时间：
2022-11
影响因子：
4.4
通讯作者：
McClure, C. Patrick
中科院分区：
文献类型：
--
作者：
Chellapuri, Akhil;Smitheman, Matthew;Chappell, Joseph G.;Clark, Gemma;Howson-Wells, Hannah C.;Berry, Louise;Ball, Jonathan K.;Irving, William L.;Tarr, Alexander W.;McClure, C. Patrick
关键词：
人副流感病毒（HPIV）由呼吸道病毒（HPIV 1和3）和正红细胞病毒（HPIV 2和4）的遗传学上不同的属的四个成员组成，在全球范围内引起显著的上呼吸道和下呼吸道感染，特别是在儿童中。然而，尽管经常进行分子诊断，但它们经常被集体考虑或完全忽略HPIV 4。因此，我们调查了临床和病毒流行病学的差异，相对较不流行的正红细胞病毒HPIV 2和4在一个地区的英国医院在四个秋季/冬季流行季节。对2013年9月1日至2017年4月12日期间诊断的所有HPIV 2或HPIV 4 RT-PCR阳性患者的临床特征进行了回顾性稽查，并对代表性样本子集中的病毒基因组片段进行了测序。所有年龄组都观察到感染，但主要是9岁以下的儿童和40岁以上的成人，HPIV 4病例几乎是HPIV 2病例的两倍。发热、血液学异常、C反应蛋白升高和住院在HPIV 2感染中比HPIV 4感染更常见。HPIV 2、HPIV 4或两者的四个季节性高峰中的每一个都与RSV的高峰密切匹配，发生在11月和12月，并在甲型流感之前。对一个病毒子集进行了部分测序，表明HPIV 2和4的多种亚型共同传播，但每个流行季节之间或有限的全球参考序列之间几乎没有变化。尽管是已知最接近的遗传亲属，但我们的数据表明HPIV 2和HPIV 4之间相关疾病的潜在差异，在HPIV 2单感染个体中观察到更多的住院治疗，但HPIV 4病例的总数更多。
Human Parainfluenza viruses (HPIV) comprise of four members of the genetically distinct genera of Respirovirus (HPIV1&3) and Orthorubulavirus (HPIV2&4), causing significant upper and lower respiratory tract infections worldwide, particularly in children. However, despite frequent molecular diagnosis, they are frequently considered collectively or with HPIV4 overlooked entirely. We therefore investigated clinical and viral epidemiological distinctions of the relatively less prevalent Orthorubulaviruses HPIV2&4 at a regional UK hospital across four autumn/winter epidemic seasons. A retrospective audit of clinical features of all HPIV2 or HPIV4 RT‐PCR‐positive patients, diagnosed between 1st September 2013 and 12th April 2017 was undertaken, alongside sequencing of viral genome fragments in a representative subset of samples. Infection was observed across all age groups, but predominantly in children under nine and adults over 40, with almost twice as many HPIV4 as HPIV2 cases. Fever, abnormal haematology, elevated C‐reactive protein and hospital admission were more frequently seen in HPIV2 than HPIV4 infection. Each of the four seasonal peaks of either HPIV2, HPIV4 or both, closely matched that of RSV, occurring in November and December and preceding that of Influenza A. A subset of viruses were partially sequenced, indicating co‐circulation of multiple subtypes of both HPIV2&4, but with little variation between each epidemic season or from limited global reference sequences. Despite being closest known genetic relatives, our data indicates a potential difference in associated disease between HPIV2 and HPIV4, with more hospitalisation seen in HPIV2 mono‐infected individuals, but a greater overall number of HPIV4 cases.
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影响因子：
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作者：
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影响因子：
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Maykowski P;Smithgall M;Zachariah P;Oberhardt M;Vargas C;Reed C;Demmer RT;Stockwell MS;Saiman L
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通讯作者：
McClure, C. Patrick
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