An increasing role of pyrethroid-resistant Anopheles funestus in malaria transmission in the Lake Zone, Tanzania.
An increasing role of pyrethroid-resistant Anopheles funestus in malaria transmission in the Lake Zone, Tanzania.
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DOI：
10.1038/s41598-021-92741-8
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发表时间：
2021-06-29
影响因子：
4.6
通讯作者：
Messenger LA
中科院分区：
文献类型：
--
作者：
Matowo NS;Martin J;Kulkarni MA;Mosha JF;Lukole E;Isaya G;Shirima B;Kaaya R;Moyes C;Hancock PA;Rowland M;Manjurano A;Mosha FW;Protopopoff N;Messenger LA
在撒哈拉以南非洲的部分地区，按蚊在疟疾传播中发挥着越来越大的作用。冈比亚亚种已被长效杀虫蚊帐有效控制。我们在坦桑尼亚西北部的86个研究群中调查了媒介种群生物学、杀虫剂耐药性和疟疾传播动态。一种。Funestus s.l.占媒介媒介的94.5%(4740/5016)，是疟疾传播的主要媒介(96.5%)，其子孢子率为3.4%，平均每月昆虫学接种率为4.57。在整个研究区观察到物种组成、丰度和传播量的微观地理异质性，这与南北集群之间的关键生态差异有关，具有明显更高的密度、比例和EIR。Funestus s.l.从南方收集来的。一种。冈比亚亚种(5.5%)密度，主要是An。Arabiens(81.1%)和An.冈比亚亚种(18.9%)，低得多，且与季节降雨量密切相关。两个人都是。Funestus s.l.还有一个。冈比亚亚种对氯氰菊酯和氯氰菊酯的抗性相似。在AN中检测到高表达的细胞色素P9K1、细胞色素P6P3、细胞色素P6P4和细胞色素P6M2，以及较高的L1014S-kdr突变频率。冈比亚亚种人口。研究结果突出表明迫切需要新的病媒控制工具来应对坦桑尼亚湖区持续的疟疾传播。
Anopheles funestus is playing an increasing role in malaria transmission in parts of sub-Saharan Africa, where An. gambiae s.s. has been effectively controlled by long-lasting insecticidal nets. We investigated vector population bionomics, insecticide resistance and malaria transmission dynamics in 86 study clusters in North-West Tanzania. An. funestus s.l. represented 94.5% (4740/5016) of all vectors and was responsible for the majority of malaria transmission (96.5%), with a sporozoite rate of 3.4% and average monthly entomological inoculation rate (EIR) of 4.57 per house. Micro-geographical heterogeneity in species composition, abundance and transmission was observed across the study district in relation to key ecological differences between northern and southern clusters, with significantly higher densities, proportions and EIR of An. funestus s.l. collected from the South. An. gambiae s.l. (5.5%) density, principally An. arabiensis (81.1%) and An. gambiae s.s. (18.9%), was much lower and closely correlated with seasonal rainfall. Both An. funestus s.l. and An. gambiae s.l. were similarly resistant to alpha-cypermethrin and permethrin. Overexpression of CYP9K1, CYP6P3, CYP6P4 and CYP6M2 and high L1014S-kdr mutation frequency were detected in An. gambiae s.s. populations. Study findings highlight the urgent need for novel vector control tools to tackle persistent malaria transmission in the Lake Region of Tanzania.
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影响因子：
2.7
作者：
Charlwood JD;Rowland M;Protopopoff N;Le Clair C
通讯作者：
Le Clair C
影响因子：
3.2
作者：
Djouaka, Rousseau;Riveron, Jacob M.;Wondji, Charles S.
通讯作者：
Wondji, Charles S.
影响因子：
3.7
作者：
Kaindoa, Emmanuel W.;Matowo, Nancy S.;Okumu, Fredros O.
通讯作者：
Okumu, Fredros O.
DOI：
10.1002/joc.5086
发表时间：
2017-10-01
期刊：
INTERNATIONAL JOURNAL OF CLIMATOLOGY
影响因子：
--
作者：
Fick, Stephen E.;Hijmans, Robert J.
通讯作者：
Hijmans, Robert J.
影响因子：
9.8
作者：
Hancock, Penelope A.;Hendriks, Chantal J. M.;Moyes, Catherine L.
通讯作者：
Moyes, Catherine L.