Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota.
Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota.
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DOI：
10.1038/s41598-018-22094-2
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发表时间：
2018-02-27
影响因子：
4.6
通讯作者：
Duan J
中科院分区：
文献类型：
--
作者：
Wei X;Tao J;Xiao S;Jiang S;Shang E;Zhu Z;Qian D;Duan J
2型糖尿病（T2 DM）是一种严重影响人类生活质量的慢性代谢性疾病，目前已引起全世界的关注。越来越多的证据表明，肠道菌群对T2 DM的发展有很大影响。泻心汤是一个传统的中药方剂，临床上用于治疗糖尿病已有数千年的历史。然而，关于XXT对肠道微生物群的调节的研究很少，这将有助于揭示它是如何工作的。在这项研究中，细菌群落分析的基础上高通量16 S rRNA基因测序。结果表明，XXT可以显着塑造肠道微生物群。XXT治疗后T2 DM大鼠肠道菌群组成发生明显变化，尤其是一些短链脂肪酸产生菌和抗炎菌，如Adlercreutzia、Alloprevotella、Barnesiella、[Eubacterium] Ventriosum群、Blautia、毛螺菌科UCG-001、Papillibacter和Prevotellaceae NK 3B 31群。此外，消糖汤还能明显改善T2 DM大鼠的高血糖、脂代谢紊乱及炎症反应。相关性分析表明，关键菌群与2型糖尿病相关指标关系密切。为进一步研究其作用机制和临床应用提供了依据。
Type 2 diabetes mellitus (T2DM), a chronic metabolic disease which severely impairs peoples’ quality of life, currently attracted worldwide concerns. There are growing evidences that gut microbiota can exert a great impact on the development of T2DM. Xiexin Tang (XXT), a traditional Chinese medicine prescription, has been clinically used to treat diabetes for thousands of years. However, few researches are investigated on the modulation of gut microbiota community by XXT which will be very helpful to unravel how it works. In this study, bacterial communities were analyzed based on high-throughput 16S rRNA gene sequencing. Results indicated that XXT could notably shape the gut microbiota. T2DM rats treated with XXT exhibited obvious changes in the composition of the gut microbiota, especially for some short chain fatty acids producing and anti-inflammatory bacteria such as Adlercreutzia, Alloprevotella, Barnesiella, [Eubacterium] Ventriosum group, Blautia, Lachnospiraceae UCG-001, Papillibacter and Prevotellaceae NK3B31 group. Additionally, XXT could also significantly ameliorate hyperglycemia, lipid metabolism dysfunction and inflammation in T2DM rats. Moreover, the correlation analysis illustrated that the key microbiota had a close relationship with the T2DM related indexes. The results probably provided useful information for further investigation on its active mechanism and clinical application.
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影响因子：
12.2
作者：
Becker, Natalie;Kunath, Julia;Blaut, Michael
通讯作者：
Blaut, Michael
影响因子：
5.1
作者：
Guariguata, L.;Whiting, D. R.;Shaw, J. E.
通讯作者：
Shaw, J. E.
影响因子：
20.1
作者：
Kelly TN;Bazzano LA;Ajami NJ;He H;Zhao J;Petrosino JF;Correa A;He J
通讯作者：
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San-huang-Xie-XIN-Tang通过ENOS和MAPK途径阻止大鼠心脏缺血/再灌注诱导的凋亡。
DOI：
10.1093/ecam/neq061
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Liou SF;Ke HJ;Hsu JH;Liang JC;Lin HH;Chen IJ;Yeh JL
通讯作者：
Yeh JL
影响因子：
2.9
作者：
Egshatyan L;Kashtanova D;Popenko A;Tkacheva O;Tyakht A;Alexeev D;Karamnova N;Kostryukova E;Babenko V;Vakhitova M;Boytsov S
通讯作者：
Boytsov S