COPB2: a transport protein with multifaceted roles in cancer development and progression.
COPB2: a transport protein with multifaceted roles in cancer development and progression.
复制标题
COPB2:一种在癌症发生和进展中具有多方面作用的转运蛋白
DOI:
10.1007/s12094-021-02630-9
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发表时间:
2021-11
期刊:
影响因子:
--
通讯作者:
Mi Y
中科院分区:
文献类型:
--
作者:
Feng Y;Lei X;Zhang L;Wan H;Pan H;Wu J;Zou M;Zhu L;Mi Y
The Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an important role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer.
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影响因子:
7.7
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Briggs JA
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Rodríguez RE