COPB2: a transport protein with multifaceted roles in cancer development and progression.

COPB2: a transport protein with multifaceted roles in cancer development and progression.
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COPB2:一种在癌症发生和进展中具有多方面作用的转运蛋白

DOI:
10.1007/s12094-021-02630-9
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发表时间:
2021-11
期刊:
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
影响因子:
--
通讯作者:
Mi Y
Mi Y
中科院分区:
其他
文献类型:
--
作者:
Feng Y;Lei X;Zhang L;Wan H;Pan H;Wu J;Zou M;Zhu L;Mi Y

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Coatomer protein complex亚基β 2 (COPB2)参与COPI Coatomer protein complex的形成,并负责高尔基体和内质网之间的囊泡运输。它在维持这些细胞器的完整性以及维持细胞稳态方面起着重要作用。更重要的是,COPB2在胚胎发育和肿瘤进展中起着关键作用。COPB2被认为是几种癌症类型的重要致癌基因,与肿瘤细胞的增殖、存活、侵袭和转移有关。在这里,我们总结了目前关于COPB2在癌症发生和进展中的作用的知识。
The Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an important role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer.
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发表时间: 2017-11-17
期刊: eLife
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