Multiple-exchange-time xenon polarization transfer contrast (MXTC) MRI: initial results in animals and healthy volunteers.
Multiple-exchange-time xenon polarization transfer contrast (MXTC) MRI: initial results in animals and healthy volunteers.
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DOI：
10.1002/mrm.23066
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发表时间：
2012-04
影响因子：
3.3
通讯作者：
Ruppert, Kai
中科院分区：
文献类型：
--
作者：
Dregely, Isabel;Ruset, Iulian C.;Mata, Jaime F.;Ketel, Jeffrey;Ketel, Steve;Distelbrink, Jan;Altes, Talissa A.;Mugler, John P., III;Miller, G. Wilson;Hersman, F. William;Ruppert, Kai
超极化氙 129 是一种用于肺部 MRI 的非侵入性造影剂，吸入后会溶解在实质结构中，从而反映肺部氧气的气体交换过程。多交换时间氙偏振传递对比 (MXTC) MRI 是 XTC MRI 技术在四个维度（3 个空间维度加交换时间）的实现。本研究的目的是评估 MXTC MRI 检测健康肺部微结构变形的敏感性，以响应重力引起的组织压缩和肺部膨胀程度。 MXTC MRI 在四只兔子和三名健康人类志愿者中进行。区域确定了两个肺功能参数，一个与组织与肺泡体积比有关，另一个与平均间隔壁厚度有关。在低肺容量时发现 MXTC MRI 参数存在显着梯度，与仰卧位成像位置重力引起的肺组织变形一致。在高肺容量时，参数通常较低并且参数值的梯度不太明显。结果表明，MXTC MRI 可以量化健康肺部微观结构的细微变化。此外，MXTC MRI 数据中仅代表参与气体交换的结构，这可能使该技术对影响气体交换的肺微结构的病理变化特别敏感。
Hyperpolarized xenon-129 is a non-invasive contrast agent for lung MRI, which upon inhalation dissolves in parenchymal structures, thus mirroring the gas-exchange process for oxygen in the lung. Multiple-exchange-time Xenon polarization Transfer Contrast (MXTC) MRI is an implementation of the XTC MRI technique in four dimensions (3 spatial dimensions plus exchange time). The aim of this study was to evaluate the sensitivity of MXTC MRI for the detection of microstructural deformations of the healthy lung in response to gravity-induced tissue compression and the degree of lung inflation. MXTC MRI was performed in four rabbits and in three healthy human volunteers. Two lung function parameters, one related to tissue- to alveolar-volume ratio and the other to average septal-wall thickness, were determined regionally. A significant gradient in MXTC MRI parameters, consistent with gravity-induced lung tissue deformation in the supine imaging position, was found at low lung volumes. At high lung volumes, parameters were generally lower and the gradient in parameter values was less pronounced. Results show that MXTC MRI permits the quantification of subtle changes in healthy lung microstructure. Further, only structures participating in gas exchange are represented in MXTC MRI data, which potentially makes the technique especially sensitive to pathological changes in lung microstructure affecting gas exchange.
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影响因子：
3.3
作者：
COXSON, HO;MAYO, JR;HOGG, JC
通讯作者：
HOGG, JC
影响因子：
3.3
作者：
BRUDIN, LH;RHODES, CG;HUGHES, JMB
通讯作者：
HUGHES, JMB
影响因子：
3.3
作者：
Hopkins, Susan R.;Henderson, A. Cortney;Prisk, G. Kim
通讯作者：
Prisk, G. Kim
影响因子：
19.7
作者：
Kauczor, HU;Hofmann, D;Thelen, M
通讯作者：
Thelen, M
DOI：
10.1164/ajrccm.159.3.9805067
发表时间：
1999-03-01
影响因子：
24.7
作者：
Coxson, HO;Rogers, RM;Hogg, JC
通讯作者：
Hogg, JC