Estimating Telomere Length Heritability in an Unrelated Sample of Adults: Is Heritability of Telomere Length Modified by Life Course Socioeconomic Status?
Estimating Telomere Length Heritability in an Unrelated Sample of Adults: Is Heritability of Telomere Length Modified by Life Course Socioeconomic Status?
复制标题
DOI：
10.1080/19485565.2015.1120645
复制
发表时间：
2016
影响因子：
1.3
通讯作者：
Zhao W
中科院分区：
文献类型：
--
作者：
Faul JD;Mitchell CM;Smith JA;Zhao W
Telomere length (TL) is a widely used marker of biological aging and is associated with an increased risk of morbidity and mortality. Recently, there has been evidence for an association between socioeconomic status (SES) and TL, particularly with measures of education and childhood SES. Individual differences in TL are also influenced by genetic factors, with heritability estimates from twin and sibling studies ranging from 34 to 82 percent. Yet unknown is the additive heritability of TL due to measured genetic variations and the extent that heritability is modified by SES. Data from the Health and Retirement Study, a nationally-representative cohort of older adults (mean 69 years), were used to provide the first estimates of molecular-based heritability of TL using genome-wide complex trait analysis (GCTA). We found that additive genetic variance contributed 28 percent (p=0.012) of total phenotypic variance of TL in the European American sample (n=3290). Estimation using the GCTA and KING Robust relationship inference methods did not differ significantly in this sample. None of the variance from the gene-by-SES interactions examined contributed significantly to the total TL variance. Estimation of heritability and genetic interaction with SES in the African American sample (n=442) was too unstable to provide reliable estimates.
登录
查看更多内容
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
DOI：
10.1038/nrg3246
发表时间：
2012-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Deary, Ian J.;Yang, Jian;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
影响因子：
8
作者：
Drury, Stacy S.;Mabile, Emily;Theall, Katherine P.
通讯作者：
Theall, Katherine P.