Cognition, reserve, and amyloid deposition in normal aging.
Cognition, reserve, and amyloid deposition in normal aging.
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DOI：
10.1002/ana.21904
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发表时间：
2010-03
影响因子：
11.2
通讯作者：
Johnson, Keith A.
中科院分区：
文献类型：
--
作者：
Rentz, Dorene M.;Locascio, Joseph J.;Becker, John A.;Moran, Erin K.;Eng, Elisha;Buckner, Randy L.;Sperling, Reisa A.;Johnson, Keith A.
确定淀粉样蛋白沉积是否与神经心理学（NP）表现受损相关，以及认知储备（CR）是否改变了这种关联。在66名正常老年人对照和17名阿尔茨海默病（AD）患者中，我们将匹兹堡化合物B（PiB）的脑保留与NP表现联系起来，并使用教育和美国国家成人阅读测试智商作为建议的代理来评估CR的影响。我们发现，在合并样本的主题，PiB保留在楔前叶是负相关的NP性能，特别是在测试的记忆功能，但也在测试的工作记忆，语义处理，语言和视觉空间感知。CR显著改变了这种关系，使得在CR水平逐渐升高时，淀粉样蛋白沉积的增加与较差的神经心理学表现的相关性较小或根本不相关。在正常对照组的子样本中，使用特别具有挑战性的记忆测试复制了淀粉样蛋白沉积对记忆性能恶化的主要影响以及与CR的相互作用。淀粉样蛋白沉积与AD患者和正常老年人的认知能力降低相关，但CR改变了这种相关性，表明CR可能对淀粉样蛋白相关的认知障碍具有保护作用。神经网络2010; 67：353 - 364
To determine whether amyloid deposition is associated with impaired neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this association. In 66 normal elderly controls and 17 patients with Alzheimer disease (AD), we related brain retention of Pittsburgh Compound B (PiB) to NP performance and evaluated the impact of CR using education and American National Adult Reading Test intelligence quotient as proposed proxies. We found in the combined sample of subjects that PiB retention in the precuneus was inversely related to NP performance, especially in tests of memory function, but also in tests of working memory, semantic processing, language, and visuospatial perception. CR significantly modified the relationship, such that at progressively higher levels of CR, increased amyloid deposition was less or not at all associated with poorer neuropsychological performance. In a subsample of normal controls, both the main effect of amyloid deposition of worse memory performance and the interaction with CR were replicated using a particularly challenging memory test. Amyloid deposition is associated with lower cognitive performance both in AD patients and in the normal elderly, but the association is modified by CR, suggesting that CR may be protective against amyloid-related cognitive impairment. ANN NEUROL 2010;67:353–364
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
--
作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
11.2
作者：
KATZMAN, R;ARONSON, M;OOI, WL
通讯作者：
OOI, WL
影响因子：
9.9
作者：
ARRIAGADA, PV;GROWDON, JH;HYMAN, BT
通讯作者：
HYMAN, BT