Effects of age and β-amyloid on cognitive changes in normal elderly people.
Effects of age and β-amyloid on cognitive changes in normal elderly people.
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DOI：
10.1016/j.neurobiolaging.2012.02.008
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发表时间：
2012-12
影响因子：
4.2
通讯作者：
Jagust WJ
中科院分区：
文献类型：
--
作者：
Oh H;Madison C;Haight TJ;Markley C;Jagust WJ
与认知功能相关的衰退在多个认知领域中很常见。β-淀粉样蛋白（Aβ）沉积是阿尔茨海默病的病理标志，也与许多老年人的认知变化有关。在这项研究中，我们检查了广泛的认知功能，以区分年龄和Aβ对衰老过程中认知的影响。使用放射性示踪剂匹兹堡化合物B（PI B）的PET成像，我们将正常老年受试者分为高PIB-老年人和低PIB-老年人，并应用序贯多变量分析（即，主成分分析[PCA]和判别分析）以获得包括多个认知领域的认知测试的概括测量。在5个认知成分中，无论Aβ水平如何，视觉记忆和执行功能的成分得分均存在显著的年龄效应。判别评分（5个认知成分的加权评分）显示年龄和Aβ均具有显著影响，并进一步与定量PIB计数相关。目前的研究结果强调了年龄和Aβ对正常老年人认知变化的影响。
Age-related decline is common in multiple cognitive domains. β-amyloid (Aβ) deposition, a pathological hallmark of Alzheimer’s disease, is also associated with cognitive changes in many older people. In this study, we examined a wide range of cognitive function in order to differentiate the effect of age and Aβ on cognition during aging. Using PET imaging with the radiotracer Pittsburgh compound B (PIB), we classified normal older subjects as High PIB-Old and Low PIB-Old and applied sequential multivariate analyses (i.e., principal components analysis [PCA] and discriminant analysis) to obtain summary measures of cognitive tests encompassing multiple cognitive domains. Among 5 cognitive components, a significant age effect was observed in component scores of visual memory and executive functions, regardless of the level of Aβ. Discriminant scores (weighted scores of the 5 cognitive components) revealed a significant effect of both age and Aβ and were further associated with quantitative PIB counts. The results of the current study highlight both effects of age and Aβ on cognitive changes in normal elderly.
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
Långström, B