A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank.
A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank.
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DOI：
10.1093/rheumatology/keab927
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发表时间：
2022-08-30
期刊：
影响因子：
5.5
通讯作者：
Tobias, Jonathan H.
中科院分区：
文献类型：
--
作者：
Faber, Benjamin G.;Ebsim, Raja;Saunders, Fiona R.;Frysz, Monika;Lindner, Claudia;Gregory, Jennifer S.;Aspden, Richard M.;Harvey, Nicholas C.;Smith, George Davey;Cootes, Timothy;Tobias, Jonathan H.
髋关节骨性关节炎（rHOA）的传统评分方法是主观的，与临床结果的关系不一致。为了提供一种更客观的rHOA评分方法，我们旨在开发一种基于DXA图像的半自动分类器，并确认其与临床结果的关系。在UK Biobank （UKB）中对髋关节DXAs进行骨赘区域标记，由此得出髋臼、股骨头上、下骨赘分级。根据最小关节间隙宽度（mJSW）测量自动获得关节间隙缩小（JSN）等级。与rHOA相关的临床结果包括髋关节疼痛、医院诊断的OA （HES OA）和全髋关节置换术。采用Logistic回归和Cox比例风险模型来检验rHOA总体分级（0-4级，由骨赘和JSN分级合并得出）与临床结果之间的关系。研究共纳入40340例患者（平均年龄63.7岁），其中81.2%无rHOA证据，18.8%为≥1级rHOA。每个部位≥1级骨赘和JSN与髋关节疼痛、HES OA和全髋关节置换术相关。根据rHOA分级，这三个临床结果的相关性逐渐增加，其中4级rHOA与全髋关节置换术的相关性最强[57.70(38.08-87.44)]。我们的新型半自动化工具为髋部DXAs的rHOA分类提供了有用的方法，因为它与临床结果有很强的渐进关系。这些发现表明，在基于DXA的大型队列研究中，DXA扫描可用于对rHOA进行分类，支持进一步的研究，未来有可能用于基于人群的筛查。
Conventional scoring methods for radiographic hip OA (rHOA) are subjective and show inconsistent relationships with clinical outcomes. To provide a more objective rHOA scoring method, we aimed to develop a semi-automated classifier based on DXA images and confirm its relationships with clinical outcomes. Hip DXAs in UK Biobank (UKB) were marked up for osteophyte area from which acetabular, superior and inferior femoral head osteophyte grades were derived. Joint space narrowing (JSN) grade was obtained automatically from minimum joint space width (mJSW) measures. Clinical outcomes related to rHOA comprised hip pain, hospital diagnosed OA (HES OA) and total hip replacement. Logistic regression and Cox proportional hazard modelling were used to examine associations between overall rHOA grade (0–4; derived from combining osteophyte and JSN grades) and the clinical outcomes. A toal of 40 340 individuals were included in the study (mean age 63.7), of whom 81.2% had no evidence of rHOA, while 18.8% had grade ≥1 rHOA. Grade ≥1 osteophytes at each location and JSN were associated with hip pain, HES OA and total hip replacement. Associations with all three clinical outcomes increased progressively according to rHOA grade, with grade 4 rHOA and total hip replacement showing the strongest association [57.70 (38.08–87.44)]. Our novel semi-automated tool provides a useful means for classifying rHOA on hip DXAs, given its strong and progressive relationships with clinical outcomes. These findings suggest DXA scanning can be used to classify rHOA in large DXA-based cohort studies supporting further research, with the future potential for population-based screening.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
7
作者：
Faber, B. G.;Baird, D.;Tobias, J. H.
通讯作者：
Tobias, J. H.
DOI：
10.1016/j.berh.2014.01.004
发表时间：
2014-02-01
影响因子：
5.2
作者：
Johnson, Victoria L.;Hunter, David J.
通讯作者：
Hunter, David J.
影响因子：
4.1
作者：
Faber BG;Ebsim R;Saunders FR;Frysz M;Lindner C;Gregory JS;Aspden RM;Harvey NC;Smith GD;Cootes T;Tobias JH
通讯作者：
Tobias JH
影响因子：
7
作者：
Altman, R. D.;Gold, G. E.
通讯作者：
Gold, G. E.