Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.
Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.
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DOI：
10.1016/j.schres.2017.07.009
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发表时间：
2018-01
影响因子：
4.5
通讯作者：
Javitt DC
中科院分区：
文献类型：
--
作者：
Avissar M;Xie S;Vail B;Lopez-Calderon J;Wang Y;Javitt DC
自20世纪90年代初以来，精神分裂症（SCZ）的失配负性（MMN）缺陷已被广泛研究，绝大多数研究使用简单的听觉古怪任务偏差，在单个声学维度（如音高或持续时间）上变化。人们越来越有兴趣使用更复杂的偏离，违反更抽象的规则，以探测高阶认知缺陷。目前尚不清楚感觉加工缺陷如何与高级认知功能障碍相比较并导致高级认知功能障碍，这可以用后来的注意依赖性听觉事件相关电位（ERP）成分如P300的子成分P3b进行研究。在这项荟萃分析中，我们比较了MMN赤字SCZ使用简单的偏差，更复杂的偏差。我们还汇总了在同一研究样本中测量MMN和P3b的研究，并检查了研究样本中MMN和P3b缺陷之间的关系。我们的分析表明，到目前为止，使用简单的偏差的研究表现出更大的赤字比那些使用复杂的偏差，在中等到大的范围内的效果大小。当考虑到在健康对照组中测量的MMN的大小时，偏差类型之间的效应量差异显着降低。P3b缺陷，而大，只是稍微大于MMN赤字（d = 0.21）。两者合计，我们的研究结果表明，MMN到简单的偏差可能仍然是最佳的SCZ的生物标志物，感觉处理功能障碍有助于显着MMN赤字和疾病的病理生理。
Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex deviants that violate more abstract rules to probe higher order cognitive deficits. It is still unclear how sensory processing deficits compare to and contribute to higher order cognitive dysfunction, which can be investigated with later attention-dependent auditory event-related potential (ERP) components such as a subcomponent of P300, P3b. In this meta-analysis, we compared MMN deficits in SCZ using simple deviants to more complex deviants. We also pooled studies that measured MMN and P3b in the same study sample and examined the relationship between MMN and P3b deficits within study samples. Our analysis reveals that, to date, studies using simple deviants demonstrate larger deficits than those using complex deviants, with effect sizes in the range of moderate to large. The difference in effect sizes between deviant types was reduced significantly when accounting for magnitude of MMN measured in healthy controls. P3b deficits, while large, were only modestly greater than MMN deficits (d = 0.21). Taken together, our findings suggest that MMN to simple deviants may still be optimal as a biomarker for SCZ and that sensory processing dysfunction contributes significantly to MMN deficit and disease pathophysiology.
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影响因子：
10.6
作者：
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通讯作者：
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