Cortisol reactivity to experimentally manipulated psychosocial stress in young adults at varied risk for depression.
Cortisol reactivity to experimentally manipulated psychosocial stress in young adults at varied risk for depression.
复制标题
皮质醇对实验操纵的年轻人的心理压力的反应性，抑郁症风险各不相同。
DOI：
10.1002/da.22125
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发表时间：
2014-01
影响因子：
7.4
通讯作者：
Garber, Judy
中科院分区：
文献类型：
--
作者：
Morris, Matthew C.;Rao, Uma;Wang, Lily;Garber, Judy
这项研究检测了102名年轻人的皮质醇和对心理社会压力任务的情感反应，这些年轻人患抑郁症的风险不同(56人缓解-抑郁，46人从未抑郁)。参与者被随机分配到压力(即社会评价威胁)或对照(即没有社会评价威胁)的条件下。对于从不抑郁的人来说，与对照条件相比，皮质醇在压力下的反应明显更大。此外，在压力条件下，从未抑郁的人的皮质醇反应明显大于缓解抑郁的人。对于有抑郁史的人，皮质醇反应在压力和对照条件下没有显著差异。与对照条件相比，压力中从未抑郁但未缓解抑郁的个体的负性情绪反应性也更高。此外，在应激和对照条件下，皮质醇反应与恢复期的负面影响呈负相关。研究结果表明，与从未抑郁的对照组相比，缓解期抑郁症患者缺乏对社会评价压力的强大皮质醇反应。未来的研究应该调查这些下丘脑-垂体-肾上腺和情感反应性改变之间独特和交互作用的联系，以及随后抑郁发作的风险。
This study examined cortisol and affective reactivity to a psychosocial stress task in 102 young adults who varied in risk for depression (56 remitted-depressed, 46 never-depressed). Participants were randomly assigned to either a stress (i.e., social-evaluative threat) or control (i.e., no social-evaluative threat) condition. For never-depressed individuals, cortisol responses were significantly greater in the stress compared to the control condition. Moreover, cortisol responses were significantly greater for never-depressed than remitted-depressed individuals in the stress condition. For individuals with a history of depression, cortisol responses did not differ significantly between the stress and control conditions. Negative affective reactivity also was higher for never-depressed, but not remitted-depressed, individuals in the stress compared to the control condition. Moreover, cortisol responses were inversely related to negative affect during the recovery phase in both stress and control conditions. Findings indicate the lack of a robust cortisol response to social evaluation stress among remitted-depressed individuals as compared to that of never depressed controls. Future studies should investigate unique and interactive links between these hypothalamic-pituitary-adrenal and affective reactivity alterations and risk for subsequent depressive episodes.
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影响因子：
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