Recovery from hybrid breakdown reveals a complex genetic architecture of mitonuclear incompatibilities
Recovery from hybrid breakdown reveals a complex genetic architecture of mitonuclear incompatibilities
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从杂交崩溃中恢复揭示了线粒体核不相容性的复杂遗传结构
DOI：
10.1111/mec.15985
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发表时间：
2021
影响因子：
4.9
通讯作者：
Burton, Ronald S.
中科院分区：
文献类型：
--
作者：
Pereira, Ricardo J.;Lima, Thiago G.;Pierce‐Ward, N. Tessa;Chao, Lin;Burton, Ronald S.
当在其基因组背景中是中性或有益的基因在外来基因组背景中变得功能上不相容时，通常实现生殖隔离，从而导致杂种中的不活力、不育或其他形式的低适合度。最近的研究表明，线粒体的相互作用是最初的不相容性，在整个类群的人口分化的早期阶段演变。然而，线粒体不相容性的基因组结构很少被阐明。我们采用实验进化方法，从桡足类Tigriopus californicus的低适应度F2种群间杂交开始，其中相容和不相容的核等位基因的频率响应于替代线粒体背景而变化。大约9代后，我们观察到一个普遍的人口规模和生存率的增加，这表明对适应不良表型的选择效率。进化群体的全基因组测序结果显示，在每个相互交叉的三个重复中，等位基因频率发生了一些一致的变化，但线粒体背景之间的模式明显不同。仅在少数区域（约6.5%的基因组）中，无论线粒体背景如何，相同的亲本等位基因都被过度表达。约33%的基因组显示等位基因频率变化与趋异选择一致，这些基因组区域的位置在线粒体背景之间存在很大差异。在87%和89%的这些基因组区域中，显性核等位基因与相关的线粒体背景相匹配，与线粒体共适应一致。这些结果表明，线粒体不亲和性具有复杂的多基因结构，在种群之间存在差异，可能会在密切相关的类群之间产生基因组范围的基因流动障碍。
Reproductive isolation is often achieved when genes that are neutral or beneficial in their genomic background become functionally incompatible in a foreign genomic background, causing inviability, sterility or other forms of low fitness in hybrids. Recent studies suggest that mitonuclear interactions are among the initial incompatibilities to evolve at early stages of population divergence across taxa. Yet, the genomic architecture of mitonuclear incompatibilities has rarely been elucidated. We employ an experimental evolution approach starting with low‐fitness F2interpopulation hybrids of the copepodTigriopus californicus, in which frequencies of compatible and incompatible nuclear alleles change in response to an alternative mitochondrial background. After about nine generations, we observe a generalized increase in population size and in survivorship, suggesting efficiency of selection against maladaptive phenotypes. Whole genome sequencing of evolved populations showed some consistent allele frequency changes across three replicates of each reciprocal cross, but markedly different patterns between mitochondrial backgrounds. In only a few regions (~6.5% of the genome), the same parental allele was overrepresented irrespective of the mitochondrial background. About 33% of the genome showed allele frequency changes consistent with divergent selection, with the location of these genomic regions strongly differing between mitochondrial backgrounds. In 87% and 89% of these genomic regions, the dominant nuclear allele matched the associated mitochondrial background, consistent with mitonuclear co‐adaptation. These results suggest that mitonuclear incompatibilities have a complex polygenic architecture that differs between populations, potentially generating genome‐wide barriers to gene flow between closely related taxa.
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细胞核整合和共同进化。
DOI：
10.1038/s41576-018-0035-9
发表时间：
2018-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Sloan DB;Warren JM;Williams AM;Wu Z;Abdel-Ghany SE;Chicco AJ;Havird JC
通讯作者：
Havird JC
影响因子：
3.3
作者：
Lima, Thiago G.;Burton, Ronald S.;Willett, Christopher S.
通讯作者：
Willett, Christopher S.
影响因子：
10.7
作者：
Griffiths JS;Kawji Y;Kelly MW
通讯作者：
Kelly MW
DOI：
10.1146/annurev-genom-082509-141720
发表时间：
2010
影响因子：
8.7
作者：
Calvo SE;Mootha VK
通讯作者：
Mootha VK
杂交带来的生态新颖性：通过加州虎的跨越隔离提高耐热性的实验证据
影响因子：
3.3
作者：
R. Pereira;Felipe S. Barreto;R. Burton
通讯作者：
R. Burton