Essential tremor as a neuropsychiatric disorder.
Essential tremor as a neuropsychiatric disorder.
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DOI：
10.1016/j.jns.2009.08.029
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发表时间：
2010-02-15
影响因子：
4.4
通讯作者：
Louis, Elan D.
中科院分区：
文献类型：
--
作者：
Louis, Elan D.
特发性（ET）震颤的传统观点是作为一个单一症状的条件，其特征在于动作震颤。在过去的十年里，研究人员已经了解到，这种情况过于简单化。首先，很明显，许多患者也有其他运动表现（例如，共济失调步态）。第二，现在认识到存在各种非运动特征，包括认知和精神特征。轻度认知变化（特别是执行功能障碍）已在几项研究中记录。最近，两项基于人群的研究表明ET与痴呆症之间存在关联。在临床上，虽然这些病例中的大多数发展为阿尔茨海默病，但这种痴呆症的神经病理学基础尚未得到充分探讨。精神病的表现包括特定的人格特征、焦虑、社交恐惧和抑郁症状。抑郁可能是疾病的主要表现，而不是对残疾的次要反应。ET的新观点是，它是一种疾病，其中心特征是动作震颤，但其中运动和非运动特征都发生。与其他神经退行性疾病一样，ET似乎不仅仅是一种运动系统疾病。对这些非运动现象的进一步研究将促进我们对疾病机制的理解，并提高与患者的临床互动质量。
The traditional view of essential (ET) tremor is as a mono-symptomatic condition characterized by action tremor. Over the past decade, researchers have learned that this picture is an over-simplification. First, it is clear that many patients also have other motor manifestations (e.g., ataxic gait). Second, the presence of a variety of non-motor features, both cognitive and psychiatric, is now appreciated. Mild cognitive changes (esp. executive dysfunction) have been documented in several studies. More recently, two population-based studies have demonstrated an association between ET and dementia. Clinically, while most of these cases developed Alzheimer’s disease, the neuropathological underpinnings of this dementia have not been fully explored. Psychiatric manifestations include specific personality traits, anxiety, social phobia, and depressive symptoms. Depression may be a primary manifestation of the illness rather than a secondary response to disability. The emerging view of ET is that it is a disease whose central feature is action tremor but in which both motor and non-motor features occur. As in other neurodegenerative conditions, ET appears to be more than a disease of the motor system. Further study of these non-motor phenomena will advance our understanding of disease mechanisms and enhance the quality of clinical interactions with patients.
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影响因子：
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通讯作者：
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