Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization.
Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization.
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DOI：
10.1038/s41598-018-23939-6
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发表时间：
2018-04-04
影响因子：
4.6
通讯作者：
Lee HH
中科院分区：
文献类型：
--
作者：
Jun SK;Yang SA;Kim YJ;El-Fiqi A;Mandakhbayar N;Kim DS;Roh J;Sauro S;Kim HW;Lee JH;Lee HH
结合粘合剂修复硬组织是医学和牙科领域的一个全球性挑战。涉及应用粘合剂和替代材料用于功能或解剖恢复的常见临床疗法仍然是次优的。具有生物活性和抑制酶介导的粘附降解作用的生物材料可以解决这个问题。在这里，我们设计了一种新的铜掺杂的生物活性玻璃纳米粒子（CuBGn），以提供多功能：金属蛋白酶（MMP）的失活和再矿化，并将CuBGn纳入树脂-牙本质粘合剂系统，这表明硬组织粘合剂中最常见的MMP介导的粘合剂降解失败，以评估拟议的治疗效果。成功制备了溶胶-凝胶衍生的生物活性玻璃纳米粒子掺杂10重量%的铜（Cu-BGn），用于释放铜离子，这是众所周知的MMP钝化剂，并以不同的浓度（高达2重量%）包含在光固化牙科粘合剂（DA）中，无填料共聚单体树脂共混物。这些治疗粘合剂（CuBGn-DA）显示出增强的（a）细胞生物活性、细胞相容性、微拉伸粘合强度和MMP失活能力。总之，掺入释放Cu离子的纳米生物活性玻璃在树脂-牙本质界面表现出多功能特性; MMP失活和再矿化，代表了延长粘合剂-硬组织（即树脂-牙本质）界面寿命的合适策略。
Restoration of hard tissue in conjunction with adhesive is a globally challenging issue in medicine and dentistry. Common clinical therapies involving application of adhesive and substitute material for functional or anatomical recovery are still suboptimal. Biomaterials with bioactivity and inhibitory effects of enzyme-mediated adhesive degradation can render a solution to this. Here, we designed a novel copper-doped bioactive glass nanoparticles (CuBGn) to offer multifunction: metalloproteinases (MMP) deactivation and remineralization and incorporated the CuBGn in resin-dentin adhesive systems, which showed most common failure of MMP mediated adhesive degradation among hard tissue adhesives, to evaluate proposed therapeutic effects. A sol-gel derived bioactive glass nanoparticles doping 10 wt% of Cu (Cu-BGn) for releasing Cu ions, which were well-known MMP deactivator, were successfully created and included in light-curing dental adhesive (DA), a filler-free co-monomer resin blend, at different concentrations (up to 2 wt%). These therapeutic adhesives (CuBGn-DA) showed enhanced (a)cellular bioactivity, cytocompatibility, microtensile bond strength and MMP deactivation-ability. In conclusion, the incorporation of Cu ions releasing nano-bioactive glass demonstrated multifunctional properties at the resin-dentin interface; MMP deactivation and remineralization, representing a suitable strategy to extend the longevity of adhesive-hard tissue (i.e. resin-dentin) interfaces.
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影响因子：
2.5
作者：
Jang, Ji-Hyun;Lee, Myoung Geun;Kim, Duck-Su
通讯作者：
Kim, Duck-Su
影响因子：
8.2
作者：
Castillo Diaz LA;Elsawy M;Saiani A;Gough JE;Miller AF
通讯作者：
Miller AF
DOI：
10.1073/pnas.1414126111
发表时间：
2014-12-09
影响因子：
11.1
作者：
Aguda, Adeleke H.;Panwar, Preety;Broemme, Dieter
通讯作者：
Broemme, Dieter
影响因子：
5
作者：
Jo, Jeong-Ki;El-Fiqi, Ahmed;Lee, Hae-Hyoung
通讯作者：
Lee, Hae-Hyoung
影响因子：
2.2
作者：
Jun, S-K;Mahapatra, C.;Lee, J-H
通讯作者：
Lee, J-H