Positive effects of brown adipose tissue on femoral bone structure.
Positive effects of brown adipose tissue on femoral bone structure.
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DOI：
10.1016/j.bone.2013.10.007
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发表时间：
2014-01
期刊：
影响因子：
4.1
通讯作者：
Torriani, Martin
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Gill, Corey M.;Rosen, Clifford J.;Klibanski, Anne;Torriani, Martin
最近的研究表明，棕色脂肪组织(BAT)和骨骼之间存在联系。本研究旨在探讨BAT对股骨结构的影响。我们研究了105例患者(男性19例，女性86例，平均年龄45.5±16.1y)，这些患者接受了F18-FDG正电子发射断层扫描/计算机断层扫描(PET/CT)检查良性疾病(n=20)或恶性肿瘤治疗成功后的随访(n=85)，从PET/CT到最后一次治疗的平均时间为14.8±18.0个月。采用正电子发射计算机断层扫描(PET/CT)测量BAT体积，CT测量股骨骨结构(股骨总横截面积、皮质CSA)，CT测量大腿肌肉CSA和大腿皮下脂肪CSA。BAT体积与总CSA、皮质CSA呈正相关，与年龄、BMI、恶性肿瘤病史无关(P<；0.05)。球拍体积与大腿肌肉CSA、大腿脂肪CSA呈正相关(p<；0.05)。当以股骨CSA总量为因变量，BAT体积、年龄和BMI为自变量时，BAT体积是股骨CSA总量的唯一预测因子。当以股骨皮质CSA为因变量，BAT体积、年龄和BMI为自变量时，BAT体积是股骨皮质CSA的唯一预测因子。蝙蝠体积是股骨结构的正向预测因子，与大腿肌肉和皮下脂肪呈正相关，可能是由肌肉介导的。这些结果进一步证明了蝙蝠对骨骼的积极作用。
Recent studies suggest a link between brown adipose tissue (BAT) and bone. The purpose of our study was to investigate the effects of BAT on femoral bone structure. We studied 105 patients (19 m, 86 f, mean age 45.5±16.1 y) who underwent F18-FDG positron emission tomography/computed tomography (PET/CT) for benign etiologies (n=20) or follow-up of successfully treated malignancies (n=85); mean time between PET/CT and last form of treatment was 14.8±18.0 months. BAT volume by PET/CT; femoral bone structure by CT (total femoral cross-sectional area (CSA), cortical CSA); thigh muscle CSA and thigh subcutaneous fat CSA by CT were assessed. There were positive correlations between BAT volume and total femoral CSA and cortical CSA, independent of age, BMI and history of malignancy (P<0.05). BAT volume correlated positively with thigh muscle CSA and thigh fat CSA (p<0.05). When total femoral CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables in a forward stepwise regression model, BAT volume was the only predictor of total femoral CSA. When femoral cortical CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables, BAT volume was the only predictor of femoral cortical CSA. BAT volume is a positive predictor of femoral bone structure and correlates positively with thigh muscle and subcutaneous fat, possibly mediated by muscle. These results provide further evidence of a positive effect of BAT on bone.
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冷激活的棕色脂肪组织是女性较高骨矿物质密度的独立预测指标。
DOI：
10.1007/s00198-012-2110-y
发表时间：
2013-04
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Lee P;Brychta RJ;Collins MT;Linderman J;Smith S;Herscovitch P;Millo C;Chen KY;Celi FS
通讯作者：
Celi FS
影响因子：
5.1
作者：
Gilsanz, Vicente;Smith, Michelle L.;Goodarzian, Fariba;Kim, Mimi;Wren, Tishya A. L.;Hu, Houchun H.
通讯作者：
Hu, Houchun H.
影响因子：
29
作者：
Seale, Patrick;Kajimura, Shingo;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
4.1
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne
影响因子：
8.2
作者：
Snijder, MB;Visser, M;Seidell, JC
通讯作者：
Seidell, JC