Controlled remineralization of enamel in the presence of amelogenin and fluoride.
Controlled remineralization of enamel in the presence of amelogenin and fluoride.
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DOI：
10.1016/j.biomaterials.2008.10.019
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发表时间：
2009-02
期刊：
影响因子：
14
通讯作者：
Moradian-Oldak, Janet
中科院分区：
文献类型：
--
作者：
Fan, Yuwei;Sun, Zhi;Moradian-Oldak, Janet
牙釉质样结构的重建一直是材料科学和牙科学的重要研究课题。釉原蛋白在调节磷酸钙晶体矿化中的重要作用已有报道。我们使用釉原蛋白，并利用一种改进的仿生沉积方法，使蚀刻釉质表面矿化，形成含有组织化针状氟化羟基磷灰石晶体的矿物层。通过SEM、XRD和FT-IR分析了重组釉原蛋白（rP 172）对涂层中矿物微观结构的影响，当rP 172浓度低于33 μg/mL时，对涂层中矿物微观结构的影响不明显。在1 mg/L F和33 μg/mL rP 172的浓度下，开始形成从釉质表面生长的熔融晶体。釉原蛋白以剂量依赖方式促进针状氟化羟基磷灰石定向成束。仿生合成的釉原蛋白氟化羟基磷灰石纳米复合材料的主要步骤之一的开发和设计的新型生物材料的未来应用在修复和恢复牙科。
Reconstructing enamel-like structures on teeth has been an important topic of study in the material sciences and dentistry. The important role of amelogenin in modulating the mineralization of organized calcium phosphate crystals has been previously reported. We used amelogenin and utilized a modified biomimetic deposition method to remineralize the surface of etched enamel to form mineral layers containing organized needle-like fluoridated hydroxyapatite crystals. The effect of a recombinant amelogenins (rP172) on the microstructure of the mineral in the coating was analyzed by SEM, XRD and FT-IR. At rP172 concentrations below 33 μg/mL, no significant effect was observed. In the presence of 1 mg/L F and at a concentration of 33 μg/mL rP172, formation of fused crystals growing from the enamel surface was initiated. Amelogenin promoted the oriented bundle formation of needle-like fluoridated hydroxyapatite in a dose dependent manner. Biomimetic synthesis of the amelogenin fluoridated hydroxyapatite nano-composite is one of the primary steps towards the development and design of novel biomaterial for future application in reparative and restorative dentistry.
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影响因子：
9.9
作者：
Chen, HF;Clarkson, BH;Mansfield, JF
通讯作者：
Mansfield, JF
影响因子：
14
作者：
Fan, Yuwei;Sun, Zhi;Moradian-Oldak, Janet
通讯作者：
Moradian-Oldak, Janet
影响因子：
--
作者：
Fowler, CE;Li, M;Margolis, HC
通讯作者：
Margolis, HC
DOI：
10.1002/jbm.10280
发表时间：
2002-12-15
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Koutsopoulos, S
通讯作者：
Koutsopoulos, S
影响因子：
1.9
作者：
Iijima, Mayumi;Du, Chang;Moradian-Oldak, Janet
通讯作者：
Moradian-Oldak, Janet