Effects of sensitivity to life stress on uncinate fasciculus segments in early adolescence.
Effects of sensitivity to life stress on uncinate fasciculus segments in early adolescence.
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DOI：
10.1093/scan/nsx065
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发表时间：
2017-09-01
影响因子：
4.2
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Ho TC;King LS;Leong JK;Colich NL;Humphreys KL;Ordaz SJ;Gotlib IH
先前的研究表明，早期生活压力（ELS）会影响钩状束（UF）的结构完整性，这是一个在整个青春期经历长期发育的额叶白质束。青春期是一个重要的过渡时期，其特点是出现内化的精神病理，如焦虑，特别是在高水平的压力敏感性个体。我们研究了104名早期青少年对ELS的敏感性、UF的结构完整性和焦虑症状之间的关系。我们进行了结构化访谈来评估ELS暴露情况，并获得了主观和客观的压力严重程度评分，从中我们得出了ELS敏感性指数。我们还获得了弥散性MRI，并进行了确定性神经束成像，以可视化UF轨迹，并从UF的三个不同部分（额叶、岛叶和颞叶）计算结构完整性的测量。我们发现，对ELS的较高敏感性预示着右额叶UF分数各向异性的降低和焦虑症状的升高。这些发现表明，在整个青春期仍处于发育阶段的额叶UF纤维最容易受到ELS敏感性提高的影响，额叶UF结构完整性的降低可能是早期压力与随后的内化精神病理之间关系的基础。
Previous research suggests that exposure to early life stress (ELS) affects the structural integrity of the uncinate fasciculus (UF), a frontolimbic white matter tract that undergoes protracted development throughout adolescence. Adolescence is an important transitional period characterized by the emergence of internalizing psychopathology such as anxiety, particularly in individuals with high levels of stress sensitivity. We examined the relations among sensitivity to ELS, structural integrity of the UF, and anxiety symptoms in 104 early adolescents. We conducted structured interviews to assess exposure to ELS and obtained subjective and objective ratings of stress severity, from which we derived an index of ELS sensitivity. We also acquired diffusion MRI and conducted deterministic tractography to visualize UF trajectories and to compute measures of structural integrity from three distinct segments of the UF: frontal, insular, temporal. We found that higher sensitivity to ELS predicted both reduced fractional anisotropy in right frontal UF and higher levels of anxiety symptoms. These findings suggest that fibers in frontal UF, which are still developing throughout adolescence, are most vulnerable to the effects of heightened sensitivity to ELS, and that reduced structural integrity of frontal UF may underlie the relation between early stress and subsequent internalizing psychopathology.
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影响因子：
26.1
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
DOI：
10.1097/01.chi.0000246065.93200.a1
发表时间：
2007-02-01
影响因子：
13.3
作者：
Baldwin, Jennifer S.;Dadds, Mark R.
通讯作者：
Dadds, Mark R.
DOI：
10.1016/j.jaac.2009.11.005
发表时间：
2010-02-01
影响因子：
13.3
作者：
Cullen, Kathryn R.;Klimes-Dougan, Bonnie;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
影响因子：
2.5
作者：
Bouwmeester, H;Wolterink, G;Van Ree, JM
通讯作者：
Van Ree, JM
影响因子：
2.9
作者：
Hasan KM;Iftikhar A;Kamali A;Kramer LA;Ashtari M;Cirino PT;Papanicolaou AC;Fletcher JM;Ewing-Cobbs L
通讯作者：
Ewing-Cobbs L