Maturational trajectories of pericortical contrast in typical brain development.
Maturational trajectories of pericortical contrast in typical brain development.
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DOI：
10.1016/j.neuroimage.2021.117974
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发表时间：
2021-07-15
期刊：
影响因子：
5.7
通讯作者：
Karama S
中科院分区：
文献类型：
--
作者：
Drakulich S;Thiffault AC;Olafson E;Parent O;Labbe A;Albaugh MD;Khundrakpam B;Ducharme S;Evans A;Chakravarty MM;Karama S
在过去的几年里，大量的工作旨在表征成熟的轨迹皮质发育。皮质周围微结构的作用，其特征在于在皮质周围的灰白质边界的灰白质对比度（GWC）和它的关系，以更传统的形态学测量的皮质形态学已经成为一种手段，检查更细粒度的神经解剖学基础的皮质变化。在这项工作中，我们的特点GWC的发展轨迹在一个有代表性的样本（n = 394）的儿童和青少年（~4至~22岁），重复扫描（1-3扫描每个主题，总扫描n = 819）。我们测试了对比度发展的线性、二次或三次轨迹是否最能描述GWC的变化。通过赤池信息准则（AIC）在整个皮层的顶点上识别最佳拟合模型。几乎整个大脑的GWC随着年龄的增长而显着变化。63%的顶点最有可能是立方轨迹，20%的顶点最有可能是二次轨迹，16%的顶点最有可能是线性轨迹。在某些区域，观察到性别的主要影响，在这些区域，男性的GWC高于女性。然而，没有性别与年龄的相互作用，发现对GWC。总之，我们的研究结果表明，在整个儿童和青少年的皮质周围边界的GWC逐渐减少。这项工作有助于努力寻求表征典型的，健康的大脑发育，并通过扩展，可以帮助阐明异常的发展轨迹。
In the last few years, a significant amount of work has aimed to characterize maturational trajectories of cortical development. The role of pericortical microstructure putatively characterized as the gray-white matter contrast (GWC) at the pericortical gray-white matter boundary and its relationship to more traditional morphological measures of cortical morphometry has emerged as a means to examine finer grained neuroanatomical underpinnings of cortical changes. In this work, we characterize the GWC developmental trajectories in a representative sample (n = 394) of children and adolescents (~4 to ~22 years of age), with repeated scans (1–3 scans per subject, total scans n = 819). We tested whether linear, quadratic, or cubic trajectories of contrast development best described changes in GWC. A best-fit model was identified vertex-wise across the whole cortex via the Akaike Information Criterion (AIC). GWC across nearly the whole brain was found to significantly change with age. Cubic trajectories were likeliest for 63% of vertices, quadratic trajectories were likeliest for 20% of vertices, and linear trajectories were likeliest for 16% of vertices. A main effect of sex was observed in some regions, where males had a higher GWC than females. However, no sex by age interactions were found on GWC. In summary, our results suggest a progressive decrease in GWC at the pericortical boundary throughout childhood and adolescence. This work contributes to efforts seeking to characterize typical, healthy brain development and, by extension, can help elucidate aberrant developmental trajectories.
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影响因子：
5.7
作者：
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