Stability of gut enterotypes in Korean monozygotic twins and their association with biomarkers and diet.
Stability of gut enterotypes in Korean monozygotic twins and their association with biomarkers and diet.
复制标题
肠道单卵双胞胎及其与生物标志物和饮食的关联的肠道肠型的稳定性。
DOI：
10.1038/srep07348
复制
发表时间：
2014-12-08
影响因子：
4.6
通讯作者：
Ko G
中科院分区：
文献类型：
--
作者：
Lim MY;Rho M;Song YM;Lee K;Sung J;Ko G
对人类肠道微生物群的研究表明，人类个体可以根据其肠道微生物群落的组成分为肠型。在这里，我们报告说，健康的韩国人的肠道菌群分为两个肠型，主要由拟杆菌（肠型1）或普雷沃氏菌（肠型2）。超过72%的配对粪便样本从单卵双胞胎对被分配到相同的肠型。我们对这些双胞胎的纵向分析表明，超过80%的人属于相同的肠型后，约2年的时间间隔。基于KEGG途径的微生物功能也分为两类。对于肠型2，100%的样品属于相同的功能簇，而对于肠型1，大约一半的样品属于每个功能簇。肠型2与高膳食纤维、各种维生素和矿物质的长期饮食习惯显著相关。在人体测量和生化性状中，血清尿酸水平与肠型相关。这些结果表明，宿主遗传学以及宿主特性，如长期饮食模式和特定的临床生物标志物可能是个体肠型的重要贡献者。
Studies on the human gut microbiota have suggested that human individuals could be categorized into enterotypes based on the compositions of their gut microbial communities. Here, we report that the gut microbiota of healthy Koreans are clustered into two enterotypes, dominated by either Bacteroides (enterotype 1) or Prevotella (enterotype 2). More than 72% of the paired fecal samples from monozygotic twin pairs were assigned to the same enterotype. Our longitudinal analysis of these twins indicated that more than 80% of the individuals belonged to the same enterotype after about a 2-year interval. Microbial functions based on KEGG pathways were also divided into two clusters. For enterotype 2, 100% of the samples belonged to the same functional cluster, while for enterotype 1, approximately half of the samples belonged to each functional cluster. Enterotype 2 was significantly associated with long-term dietary habits that were high in dietary fiber, various vitamins, and minerals. Among anthropometrical and biochemical traits, the level of serum uric acid was associated with enterotype. These results suggest that host genetics as well as host properties such as long-term dietary patterns and a particular clinical biomarker could be important contributors to the enterotype of an individual.
登录
查看更多内容
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5.1
作者：
Rajilic-Stojanovic, Mirjana;Heilig, Hans G. H. J.;de Vos, Willem M.
通讯作者：
de Vos, Willem M.
影响因子：
4.4
作者：
Roager, Henrik M.;Licht, Tine R.;Bahl, Martin I.
通讯作者：
Bahl, Martin I.
影响因子：
3.6
作者：
Maggini, Silvia;Wintergerst, Eva S.;Hornig, Dietrich H.
通讯作者：
Hornig, Dietrich H.
影响因子：
48
作者：
Segata, Nicola;Waldron, Levi;Ballarini, Annalisa;Narasimhan, Vagheesh;Jousson, Olivier;Huttenhower, Curtis
通讯作者：
Huttenhower, Curtis