Indirect Proton MR Imaging and Kinetic Analysis of (17)O-Labeled Water Tracer in the Brain.
Indirect Proton MR Imaging and Kinetic Analysis of (17)O-Labeled Water Tracer in the Brain.
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DOI：
10.2463/mrms.mp.2017-0094
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发表时间：
2018-07-10
期刊：
影响因子：
--
通讯作者：
Sasaki M
中科院分区：
文献类型：
--
作者：
Kudo K;Harada T;Kameda H;Uwano I;Yamashita F;Higuchi S;Yoshioka K;Sasaki M
基于脑实质和脑脊液（CSF）的动力学分析，评价了17 O成像稳态序列的可行性。机构审查委员会批准了这项前瞻性研究，并提供了书面知情同意书。分别在5名和9名参与者中使用3 T扫描仪使用不同参数进行动态2D或3D稳态序列。在两次连续动态扫描期间，在第一次扫描中静脉内施用生理盐水用于对照目的，在第二次扫描中施用20%17O标记的水（1 mL/Kg）。计算相对于基线的信号变化，并对所有体素进行曲线的动力学分析。在脑实质、脉络丛和CSF空间中进行感兴趣区域分析。对于大多数成像参数，17 O组的平均信号下降显著大于对照组。不同的动力学参数之间的脑实质和CSF空间观察。脑脊液间隙和脉络丛的平均和最大信号下降明显大于脑实质。与脑实质相比，CSF空间中的17 O的团注到达、达峰时间和动力学曲线的第一时刻延迟。脑室和蛛网膜下腔之间也存在显著差异。稳态序列是可行的间接17 O成像与合理的时间分辨率，这一结果是潜在的重要的水动力学和水通道蛋白功能的分析几种疾病。
The feasibility of steady-state sequences for 17O imaging was evaluated based on a kinetic analysis of the brain parenchyma and cerebrospinal fluid (CSF). The institutional review board approved this prospective study with written informed consent. Dynamic 2D or 3D steady-state sequences were performed in five and nine participants, respectively, with different parameters using a 3T scanner. During two consecutive dynamic scans, saline was intravenously administered for control purposes in the first scan, and 20% 17O-labeled water (1 mL/Kg) was administered in the second scan. Signal changes relative to the baseline were calculated, and kinetic analyses of the curves were conducted for all voxels. Region of interest analysis was performed in the brain parenchyma, choroid plexus, and CSF spaces. Average signal drops were significantly larger in the 17O group than in the controls for most of the imaging parameters. Different kinetic parameters were observed between the brain parenchyma and CSF spaces. Average and maximum signal drops were significantly larger in the CSF spaces and choroid plexus than in the brain parenchyma. Bolus arrival, time to peak, and the first moment of dynamic curves of 17O in the CSF space were delayed compared to that in the brain parenchyma. Significant differences between the ventricle and subarachnoid space were also noted. Steady-state sequences are feasible for indirect 17O imaging with reasonable temporal resolution; this result is potentially important for the analysis of water kinetics and aquaporin function for several disorders.
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影响因子：
3.3
作者：
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影响因子：
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作者：
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DOI：
10.23736/s0392-0488.16.05248-2
发表时间：
2017-08-01
影响因子：
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作者：
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