Relationship between alcohol co-ingestion and outcome in profenofos self-poisoning - A prospective case series.
Relationship between alcohol co-ingestion and outcome in profenofos self-poisoning - A prospective case series.
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DOI：
10.1371/journal.pone.0200133
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Eddleston M
中科院分区：
文献类型：
--
作者：
Dhanarisi HKJ;Gawarammana IB;Mohamed F;Eddleston M
酒精摄入对有机磷(OP)杀虫剂自毒结局的重要性仅针对相对亲水性的二甲基杀虫剂乐果进行了研究。目的：评价乙醇对S-烷基乳油杀虫剂丙硫磷急性中毒的治疗作用。人口统计学和临床数据，包括饮酒史，是从所有急性中毒病例中前瞻性收集的，农业丙溴磷EC50在七年内提交给斯里兰卡的两家医院。在1859例急性有机磷农药中毒患者中，243例(13.1%)报告摄入了丙溴磷(男性182/243，74.9%)。/243中报告了酒精共摄入(26.3%)。所有报告饮酒的患者均为男性(/[100%]vs118/179[65.9%]未报告饮酒，p<；0.001)。与未同时饮酒的患者相比，报告饮酒的患者死亡(10/[15.6%]比10/179[5.6%]；p=0.013)和需要插管的患者(13/[20.3%]比16/179[8.9%]，p=0.016)更多。采用多因素Logistic回归分析，控制估计摄入量，年龄(年龄和GT：35岁比≤：35岁，OR11.1[2.5~48.9])和饮酒(OR3.1[1.2~7.9])与死亡风险增加独立相关。插管风险的增加独立地与年龄(年龄和≤：35岁与≤35岁的OR3.2[1.6至6.6])和饮酒有关(OR3.2[1.6至6.4])。酒精共摄取史，以及年龄较大，独立地与丙溴磷自我中毒患者的较差结果有关。
The importance of alcohol co-ingestion for outcome in organophosphorus (OP) insecticide self-poisoning has only been studied for the relatively hydrophilic dimethyl insecticide, dimethoate. We aimed to assess the effect of alcohol in acute poisoning with the lipophilic S-alkyl OP insecticide, profenofos. Demographic and clinical data, including an alcohol history, were prospectively collected from all cases of acute poisoning with agricultural profenofos EC50 presenting to two Sri Lankan hospitals over seven years. Of 1859 patients with acute OP insecticide self-poisoning, 243 (13.1%) reported ingestion of profenofos (male 182/243, 74.9%). Alcohol co-ingestion was reported by 64/243 (26.3%). All patients reporting alcohol co-ingestion were male (64/64 [100%] vs 118/179 [65.9%] not reporting alcohol ingestion, p<0.001). More patients reporting alcohol co-ingestion died (10/64 [15.6%] vs 10/179 [5.6%]; p = 0.013) and required intubation (13/64 [20.3%] vs 16/179 [8.9%], p = 0.016) compared to those who did not co-ingest alcohol. Using multi-logistic regression, controlling for the estimated dose ingested, age (OR 11.1 [2.5 to 48.9] for age > 35 years vs ≤35 years) and alcohol co-ingestion (OR 3.1 [1.2 to 7.9]) were independently associated with increased risk of death. Increased risk of intubation was independently associated with age (OR 3.2 [1.6 to 6.6] for age > 35 years vs ≤35 years) and alcohol co-ingestion (OR 3.2 [1.6 to 6.4]). A history of alcohol co-ingestion, as well as older age, is independently associated with worse outcome in patients’ self-poisoned with profenofos.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
影响因子：
2.8
作者：
Moon, Jeong Mi;Chun, Byeong Jo
通讯作者：
Chun, Byeong Jo
DOI：
10.3200/aeoh.59.8.418-425
发表时间：
2004-08-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Von Osten, JR;Epomex, C;Guilhermino, L
通讯作者：
Guilhermino, L
影响因子：
4.6
作者：
Lee, Young Hwan;Oh, Young Taeck;Park, Seung Min
通讯作者：
Park, Seung Min
影响因子：
168.9
作者：
Eddleston, Michael;Buckley, Nick A.;Eyer, Peter;Dawson, Andrew H.
通讯作者：
Dawson, Andrew H.