High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.
High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent.
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DOI：
10.1002/mrm.22154
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发表时间：
2009-12
影响因子：
3.3
通讯作者：
Johnson, G. Allan
中科院分区：
文献类型：
--
作者：
Howles, Gabriel P.;Ghaghada, Ketan B.;Qi, Yi;Mukundan, Srinivasan, Jr.;Johnson, G. Allan
高分辨率磁共振血管成像已经成为研究人类疾病小鼠模型的有用工具。小鼠的磁共振血管成像通常使用飞行时间对比度进行。在这项工作中，一种新的长循环血池造影剂-表面结合的脂质纳米粒(SC-Gd脂质体)-被用于小鼠神经血管磁共振血管成像。总共对12只小鼠进行了成像。扫描参数针对飞行时间和SC-Gd对比度进行了优化。与飞行时间对比剂相比，Sc-Gd脂质体(0.08 mmol/kg)能够改善小血管对比噪声比、更大视野、更短扫描时间以及静脉结构的成像。对于有限的视野，飞行时间和SC-Gd没有显著差异；然而，当视野覆盖整个大脑(P<；0.001)或整个神经血管轴(P<；0.001)时，SC-Gd提供了更好的对比度噪声比。SC-Gd可以获得高分辨率磁共振血管成像(52×52×100微米或0.27nL)，在可比扫描时间(~45min)下，对比噪声比高123%(P<；0.001)。另外，使用SC-Gd脂质体可获得高分辨率磁共振血管成像(0.27nL)，对比度噪声比(P<；0.001)提高32%，扫描时间缩短75%(12分钟)。
High-resolution magnetic resonance angiography is already a useful tool for studying mouse models of human disease. Magnetic resonance angiography in the mouse is typically performed using time-of-flight) contrast. In this work, a new long-circulating blood-pool contrast agent—a liposomal nanoparticle with surface-conjugated gadolinium (SC-Gd liposomes)—was evaluated for use in mouse neurovascular magnetic resonance angiography. A total of 12 mice were imaged. Scan parameters were optimized for both time-of-flight and SC-Gd contrast. Compared to time-of-flight contrast, SC-Gd liposomes (0.08 mmol/kg) enabled improved small-vessel contrast-to-noise ratio, larger field of view, shorter scan time, and imaging of venous structures. For a limited field of view, time-of-flight and SC-Gd were not significantly different; however, SC-Gd provided better contrast-to-noise ratio when the field of view encompassed the whole brain (P < 0.001) or the whole neurovascular axis (P < 0.001). SC-Gd allowed acquisition of high-resolution magnetic resonance angiography (52 × 52 × 100 micrometer3 or 0.27 nL), with 123% higher (P < 0.001) contrast-to-noise ratio in comparable scan time (~45 min). Alternatively, SC-Gd liposomes could be used to acquire high-resolution magnetic resonance angiography (0.27 nL) with 32% higher contrast-to-noise ratio (P < 0.001) in 75% shorter scan time (12 min).
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