Temporal Optic Disc Microvasculature Dropout in Glaucoma.
Temporal Optic Disc Microvasculature Dropout in Glaucoma.
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DOI：
10.1167/iovs.64.11.6
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发表时间：
2023-08-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
目的探讨原发性开角型青光眼（POAG）患者局灶性颞侧视盘微血管脱落（MvD-D）的临床特点。187名POAG患者的187只眼睛在扫频源光学相干断层扫描血管造影（SS-OCTA）上患有MvD-D。根据中央凹-布鲁赫膜（BM）开口轴上下45°范围内的颞叶MvD-D的存在分为三组：（第1组，孤立性局灶性颞叶MvD-D; 44只眼），颞上/下MvD-D（2组，MvD-D仅在颞上或颞下区; 78只眼）和弥漫性颞叶MvD-D（第3组，MvD-D跨越≥ 2个连续扇区，其中至少一个是颞叶扇区; 65只眼）。第1组的眼轴长度显著较长，β区乳头旁萎缩，无BM。水平倾斜角和椭圆度指数也明显大于其他两组（P < 0.001）。第1组颞区视网膜神经纤维层（RNFL）明显薄于第2组（P < 0.001），尽管其他区域的厚度相似（P > 0.05）。除鼻、颞、颞上区外，第3组的视野平均偏差和RNFL均显著低于其他两组（P < 0.05）。SS-OCTA检测到的局灶性颞叶MvD-D与较长的眼轴长度以及视盘和视乳头旁区的相关后续形态学变化相关。这表明，视神经盘的轴向伸长随之而来的拉伸可能会导致颞部视神经盘微血管的缺乏。
To assess the clinical characteristics of focal temporal optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) patients. One hundred and eighty-seven eyes of 187 POAG patients having MvD-D on Swept-Source optical coherence tomography angiography (SS-OCTA) were enrolled. Three groups were categorized according to the presence of temporal MvD-D within the upper and lower 45° of the fovea-Bruch's membrane (BM) opening axis: focal temporal MvD-D (Group 1, isolated focal temporal MvD-D; 44 eyes), supero/inferotemporal MvD-D (Group 2, MvD-D only in superotemporal or inferotemporal sector; 78 eyes), and diffuse temporal MvD-D (Group 3, MvD-D spanning ≥ 2 consecutive sectors, at least one of which being temporal sector; 65 eyes). Group 1 had a significantly longer axial length and β-zone parapapillary atrophy without BM. There also was a larger horizontal tilt angle and ovality index than the other two groups (P < 0.001). Group 1 had a significantly thinner retinal nerve fiber layer (RNFL) in the temporal sector than did Group 2 (P < 0.001), despite similar thicknesses in all other areas (P > 0.05). Group 3 had significantly worse visual field mean deviation and thinner RNFL than the other two groups in all areas other than the nasal, temporal, and superotemporal sectors (P < 0.05). Focal temporal MvD-D detected by SS-OCTA was associated with a longer axial length and related subsequent morphological changes of the optic disc and parapapillary area. This suggests that stretching of the optic disc consequent on axial elongation may lead to absence of temporal optic disc microvasculature.
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影响因子：
4.4
作者：
Araie M;Iwase A;Sugiyama K;Nakazawa T;Tomita G;Hangai M;Yanagi Y;Murata H;Tanihara H;Burgoyne CF;Chauhan BC
通讯作者：
Chauhan BC
影响因子：
4.1
作者：
Kim, Ji-Ah;Kim, Tae-Woo;Mari, Jean Martial
通讯作者：
Mari, Jean Martial
影响因子：
4.2
作者：
Kwon, Ji Min;Weinreb, Robert N.;Suh, Min Hee
通讯作者：
Suh, Min Hee
影响因子：
4.2
作者：
Kwon JM;Weinreb RN;Zangwill LM;Suh MH
通讯作者：
Suh MH
影响因子：
4.2
作者：
Chu Z;Weinstein JE;Wang RK;Pepple KL
通讯作者：
Pepple KL