Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population.
Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening-Minimum Rim Width in a Normal Japanese Population.
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DOI：
10.1167/iovs.17-22057
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发表时间：
2017-08-01
影响因子：
4.4
通讯作者：
Chauhan BC
中科院分区：
文献类型：
--
作者：
Araie M;Iwase A;Sugiyama K;Nakazawa T;Tomita G;Hangai M;Yanagi Y;Murata H;Tanihara H;Burgoyne CF;Chauhan BC
目的：确定以BMO为中心的Bruch‘s膜开放(BMO)、BMO-最小边缘宽度(BMO-MRW)和视网膜周围神经纤维层厚度(RNFLT)的决定因素，并在日本正常人群中对这些参数进行特征分析。对258只正常日本人的258只眼的视神经头、视乳头周围和黄斑视网膜进行了光谱域光学相干断层扫描，平均年龄为51.7(18.2)岁。BMO面积、BMO-MRW、RNFLT(用3.5 mm直径圆周扫描测量)都是相对于眼特定中心凹到BMO(FoBMO)轴的测量和分析。对每个受试者随机选择一只眼睛进行分析。使用多元回归分析来确定参数的决定因素。生物膜覆盖面积平均为2.06mm2，全球生物膜覆盖面积平均为305.5(50.0)μm，全球生物膜覆盖面积平均为101.8(9.6)μm，−角平均为7.8°(3.8°)。全球BMO-MRW和RNFlt之间存在中等程度的相关性(r=0.337；P<；0.001)，而分区相关性在上颞部最高(r=0.500；P<；0.001)，在鼻部最低(r=0.117；P=0.063)。在−为1.04μm/y(P<；0.001)和−为0.12μm/y(P=0.001)时，全球BMO-MRW和RNFlt随着年龄的增长而下降，在调整其他因素后，前者与BMO面积呈负相关(P=0.001)，后者与BMO面积呈正相关(R2分别为0.191和0.272)。BMO面积与眼轴长度呈正相关(P=0.023)，与年龄呈负相关(P<；0.001)(R2=0.157)。BMO-MRW和RNFLT随年龄增长而下降，二者与BMO面积的关系存在差异。BMO面积与轴长呈正相关，与年龄呈负相关。
To identify determinants of Bruch's membrane opening (BMO), and BMO–minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) centered on BMO center and characterize these parameters in a normal Japanese population. Spectral-domain optical coherence tomography images of optic nerve head and circumpapillary and macular retina were obtained in 258 eyes of 258 normal Japanese with mean (standard deviation) age of 51.7 (18.2) years. BMO area, BMO-MRW, RNFLT (measured with a 3.5-mm-diameter circle scan) were all acquired and analyzed relative to the eye-specific fovea to BMO (FoBMO) axis. One randomly selected eye of each subject was analyzed. Multiple regression analysis was used to identify determinants to the parameters. BMO area, global BMO-MRW, RNFLT, and FoBMO angle averaged 2.06 (0.45) mm2, 305.5 (50.0) μm, 101.8 (9.6) μm, and −7.8° (3.8°), respectively. There was a modest correlation between global BMO-MRW and RNFLT (r = 0.337; P < 0.001), while the sectorwise correlations were highest in the superior-temporal sector (r = 0.500; P < 0.001) and lowest in the nasal sector (r = 0.117; P = 0.063). Global BMO-MRW and RNFLT declined with age at −1.04 μm/y (P < 0.001) and −0.12 μm/y (P = 0.001), and the former correlated negatively (P = 0.001) and the latter positively (P < 0.001) with BMO area after adjustment for other factors (R2 = 0.191 and 0.272, respectively). BMO area correlated positively with axial length (P = 0.023) and negatively with age (P < 0.001) (R2 = 0.157). BMO-MRW and RNFLT declined with age with a difference between them in their relationship to BMO area. BMO area positively correlated with axial length and negatively with age.
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影响因子：
13.7
作者：
Abe, Haruki;Shirakashi, Motohiro;Yamamoto, Tetsuya
通讯作者：
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影响因子：
4.4
作者：
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影响因子：
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通讯作者：
Garway-Heath, D. F.