Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons.
Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons.
复制标题
由活性感觉神经元激活蛋白-β调节果蝇造血部位。
DOI：
10.1038/ncomms15990
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发表时间：
2017-07-27
影响因子：
16.6
通讯作者：
Brückner K
中科院分区：
文献类型：
--
作者：
Makhijani K;Alexander B;Rao D;Petraki S;Herboso L;Kukar K;Batool I;Wachner S;Gold KS;Wong C;O'Connor MB;Brückner K
动物发育、组织稳态和疾病中的一个突出问题是细胞群如何适应感觉输入。在果蝇幼虫发育过程中，造血部位与外周神经系统（PNS）的感觉神经元簇直接接触，血细胞（血细胞）需要PNS才能存活并招募到这些微环境中，称为造血口袋。本文报道了TGF-β家族配体Activin-β在PNS的感觉神经元中表达，并调节血细胞的增殖和粘附。这些血细胞反应依赖于PNS活性，如通过激动剂处理和感觉神经元的瞬时沉默所示。激活素-β在这种调节中具有关键作用，这从报告基因表达和突变体分析中显而易见。这种局部感觉神经元控制血细胞适应的机制与脊椎动物造血祖细胞和组织巨噬细胞的独立骨髓系统的进化相似，其受局部微环境的调节仍然不确定。果蝇幼虫的造血部位需要局部外周神经系统才能使血细胞存活和增殖，但这是如何介导的尚不清楚。在这里，作者确定了来自感觉神经元的激活素-β作为血细胞的信号传导，影响增殖和粘附。
An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined. Hematopoietic sites in the Drosophila larva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion.
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影响因子：
9.2
作者：
Clark, Rebecca I.;Woodcock, Katie J.;Geissmann, Frederic;Trouillet, Celine;Dionne, Marc S.
通讯作者：
Dionne, Marc S.
DOI：
10.1073/pnas.1319116111
发表时间：
2014-04-15
影响因子：
11.1
作者：
Ghosh, Arpan C.;O'Connor, Michael B.
通讯作者：
O'Connor, Michael B.
影响因子：
4.6
作者：
Gibbens, Ying Y.;Warren, James T.;O'Connor, Michael B.
通讯作者：
O'Connor, Michael B.
影响因子：
64.5
作者：
Chang RB;Strochlic DE;Williams EK;Umans BD;Liberles SD
通讯作者：
Liberles SD
影响因子：
2.5
作者：
Im, Seol Hee;Galko, Michael J.
通讯作者：
Galko, Michael J.