Radiolabeled nanoparticles for multimodality tumor imaging.
Radiolabeled nanoparticles for multimodality tumor imaging.
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用于多模态肿瘤成像的放射性标记纳米颗粒
作者：
Xing Y;Zhao J;Conti PS;Chen K
每种成像方式都有其独特的优势。多模态成像利用两种或多种成像方式的优势，可以提供整体的结构、功能和分子信息，为提高诊断和治疗监测能力提供了前景。多模态、多功能的分子成像装置对癌症的诊断和治疗具有重要的价值，极大地促进了基于放射性核素的多模态分子成像技术的发展。在过去的十年中，具有固有特性的放射性标记纳米颗粒在多模态肿瘤成像中引起了极大的兴趣。各种放射性标记纳米粒子的开发取得了重大突破，这些纳米粒子可以作为新型的癌症诊断工具用于多模态成像系统。预计多功能放射性标记纳米粒子的定量多模态成像将以实时的方式提供准确和精确的癌症生物特征评估，从而为个性化癌症医学铺平道路。本文综述了利用不同类型的纳米颗粒开发多模态成像探针的优势和挑战，并总结了放射性标记纳米颗粒在肿瘤多模态成像中的应用进展。在翻译放射性标记纳米粒子到临床的关键问题也进行了讨论。
Each imaging modality has its own unique strengths. Multimodality imaging, taking advantages of strengths from two or more imaging modalities, can provide overall structural, functional, and molecular information, offering the prospect of improved diagnostic and therapeutic monitoring abilities. The devices of molecular imaging with multimodality and multifunction are of great value for cancer diagnosis and treatment, and greatly accelerate the development of radionuclide-based multimodal molecular imaging. Radiolabeled nanoparticles bearing intrinsic properties have gained great interest in multimodality tumor imaging over the past decade. Significant breakthrough has been made toward the development of various radiolabeled nanoparticles, which can be used as novel cancer diagnostic tools in multimodality imaging systems. It is expected that quantitative multimodality imaging with multifunctional radiolabeled nanoparticles will afford accurate and precise assessment of biological signatures in cancer in a real-time manner and thus, pave the path towards personalized cancer medicine. This review addresses advantages and challenges in developing multimodality imaging probes by using different types of nanoparticles, and summarizes the recent advances in the applications of radiolabeled nanoparticles for multimodal imaging of tumor. The key issues involved in the translation of radiolabeled nanoparticles to the clinic are also discussed.
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