Familial Hypercholesterolemia Biomarker Distribution in Dried Blood Spots.
Familial Hypercholesterolemia Biomarker Distribution in Dried Blood Spots.
复制标题
干血斑中的家族性高胆固醇血症生物标志物分布。
DOI：
10.1016/j.jpeds.2023.113469
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Peterson,AmyL
中科院分区：
文献类型：
--
作者：
Held,PatriceK;Lasarev,Michael;Zhang,Xiao;Wiberley-Bradford,AmyE;Campbell,Kristin;Horner,Vanessa;Shao,Xiangqiang;Benoy,Megan;Dodge,AnnM;Peterson,AmyL
目的探讨新生儿总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白B(ApoB)作为新生儿家族性高胆固醇血症候选标志物的分布规律，并考虑胎龄、出生体重、性别、种族等潜在混杂因素。每个生物标志物的浓度以中位数的倍数报告，重点描述基于出生体重、胎龄、性别和种族的第99个百分位值。结果低密度脂蛋白和载脂蛋白B的分布曲线呈尾部极高的分布曲线，而总胆固醇的分布较低，变化幅度最小。早孕儿和低出生体重儿apoB中值的第99个百分位数显著高于中位数，而TC和LDL-C则不明显。基于性别和种族的生物标记物浓度差异很小。与夏季相比，各生物标志物在冬季的浓度最高。结论低密度脂蛋白和载脂蛋白B具有分布曲线，支持新生儿家族性高胆固醇血症的筛查。未来的研究需要将新生儿筛查结果与分子测试相关联，以验证这两个生物标志物，以及童年后期测量的胆固醇水平。
ObjectiveTo evaluate distribution profiles of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apoB) as candidate markers of familial hypercholesterolemia in newborns, taking into consideration potential confounding factors, such as gestational age, birth weight, sex, and race.Study designTC, LDL-C, and apoB were measured from 10 000 residual deidentified newborn dried blood spot cards. Concentrations for each biomarker were reported as multiples of the median, with emphasis on describing the 99th percentile values based on birth weight, gestational age, sex, and race. Seasonal variation of biomarkers was also explored.ResultsLDL-C and apoB had distribution curves with tails showing extreme elevation, whereas the distribution of TC was less elevated and had the smallest range. Neonates born at early gestational age and low birth weight had significantly greater 99th percentile of multiples of the median values for apoB but not TC or LDL-C. Differences in biomarker concentration based on sex and race were minimal. All biomarkers showed greatest concentrations in the winter as compared with summer months.ConclusionsLDL-C and apoB had distribution curves supporting candidacy for neonatal familial hypercholesterolemia screening. Future studies are needed to correlate newborn screening results with molecular testing to validate these 2 biomarkers, along with measured cholesterol levels later in childhood.
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微血管的神经元控制。
影响因子：
18.2
作者：
S. Rosell
通讯作者：
S. Rosell
影响因子：
8.3
作者：
S. Z. Langer;N. Shepperson;R. Massingham
通讯作者：
S. Z. Langer;N. Shepperson;R. Massingham
影响肾血流自动调节的一些因素的相互关系。
DOI：
10.1111/j.1748-1716.1964.tb02952.x
发表时间：
1964
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
B. Folkow;J. Langston
通讯作者：
J. Langston
血管的神经体液控制：未来的一些方向
影响因子：
3
作者：
G. Burnstock
通讯作者：
G. Burnstock
影响因子：
3
作者：
LANGER, SZ;HICKS, PE
通讯作者：
HICKS, PE