Monitoring silver diamine fluoride application with optical coherence tomography and thermal imaging: An in vitro proof of concept study.
Monitoring silver diamine fluoride application with optical coherence tomography and thermal imaging: An in vitro proof of concept study.
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光学相干断层扫描和热成像监测银二胺氟化物的应用：概念研究的体外证明。
DOI：
10.1002/lsm.23528
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发表时间：
2022-07
影响因子：
2.4
通讯作者：
Fried, Daniel
中科院分区：
文献类型：
--
作者：
Abdelaziz, Marwa;Yang, Vincent;Chang, Nai-Yuan Nicholas;Darling, Cynthia;Fried, William;Seto, Jong;Fried, Daniel
关键词：
本研究的目的是表明，光学相干断层扫描（OCT）和热成像可用于监测银二胺氟化物（SDF）治疗后，随着时间的推移，龋齿病变的结构和活动的变化。在牙釉质和牙本质牛块上形成人工龋损。将每个块划分为五个窗口，其中中央三个窗口暴露于脱矿溶液以产生损伤：一个声音窗口用作声音对照（SC），一个声音窗口暴露于SDF以用作测试对照（SCT），一个损伤窗口用作损伤对照（LC），一个损伤窗口接受一次SDF应用（L1），而另一个病变窗口接受SDF的两次应用（L2）。在SDF应用之前使用OCT扫描每个窗口，并且随后每周扫描一次，在初始SDF治疗后持续12周。监测由于病变和SDF引起的反射率增加的峰的平均强度和宽度的变化沿着以及距离表面180 µm深度处的强度，代表通过病变的光穿透。还使用热成像相机监测在空气干燥期间每个窗户的热损失ΔQ（随时间积分的温度）的变化。横向显微放射照相术（TMR）和高分辨率显微镜也用于分析选定的样品。SDF应用后，OCT图像中釉质和牙本质的声音和病变区域的反射率和光穿透率均发生了显著变化。热成像显示，SDF应用后，釉质和牙本质的声音和损伤区域的渗透性变化的ΔQ指示的显着差异。
The purpose of this study was to show that optical coherence tomography (OCT) and thermal imaging can be used to monitor changes in the structure and activity of caries lesions over time after treatment with silver diamine fluoride (SDF). Artificial caries lesions were formed on enamel and dentin bovine blocks. Each block was partitioned into five windows with the central three windows exposed to a demineralization solution to create lesions: one sound window served as a sound control (SC), one sound window was exposed to SDF to serve as a test control (SCT), one lesion window served as a lesion control (LC), one lesion window received one application of SDF (L1), while the other lesion window received two applications of SDF (L2). Each window was scanned using OCT before SDF application, and every week subsequently, for 12 weeks after initial SDF treatment. Changes in the mean intensity and the width of the peak of increased reflectivity due to the lesion and SDF along with the intensity at a depth of 180 µm from the surface representing optical penetration through the lesion were monitored. Changes in the heat lost, ΔQ (temperature integrated over time) of each window during drying with air were also monitored using a thermal imaging camera. Transverse microradiography (TMR), and high‐resolution microscopy were also used for the analysis of selected samples. The reflectivity and optical penetration of sound and lesion areas of enamel and dentin manifested significant changes in OCT images after SDF application. Thermal imaging showed significant differences in ΔQ indicative of permeability changes in the sound and lesion areas of enamel and dentin after SDF application.
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影响因子：
3.5
作者：
Ando, Masatoshi;Ferreira-Zandona, Andrea G.;Stookey, George K.
通讯作者：
Stookey, George K.
影响因子：
3.5
作者：
Chan, Kenneth H.;Fried, Daniel
通讯作者：
Fried, Daniel
DOI：
10.1109/jstqe.2015.2477396
发表时间：
2016-05-01
影响因子：
4.9
作者：
Lee, Kisung;Danilina, Anna V.;Meglinski, Igor
通讯作者：
Meglinski, Igor
影响因子：
2.4
作者：
Chan, Kenneth H.;Tom, Henry;Fried, Daniel
通讯作者：
Fried, Daniel
DOI：
10.1117/12.2011014
发表时间：
2013-03-25
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
--
作者：
Fried, Daniel;Staninec, Michal;Pelzner, Roger B
通讯作者：
Pelzner, Roger B