Insecticide control of vector-borne diseases: when is insecticide resistance a problem?
Insecticide control of vector-borne diseases: when is insecticide resistance a problem?
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DOI：
10.1371/journal.ppat.1001000
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发表时间：
2010-08-05
期刊：
影响因子：
6.7
通讯作者：
Gandon S
中科院分区：
文献类型：
--
作者：
Rivero A;Vézilier J;Weill M;Read AF;Gandon S
许多最危险的人类疾病是由昆虫媒介传播的。经过几十年的反复使用杀虫剂，所有这些病媒物种都表现出对杀虫剂产生抗药性的能力。对杀虫剂的抗药性通常被认为会破坏对病媒传播疾病的控制，因为它会增加在杀虫剂处理后存活下来的病媒数量。然而，病媒控制失败不一定导致疾病控制失败。在这里，我们审查的证据表明，杀虫剂耐药性可能会对质量的载体，特别是对寄生虫传播的三个关键决定因素：载体寿命，能力和行为的影响。我们认为，在某些情况下，杀虫剂的耐药性可能会导致减少病媒寿命，减少传染性，或在行为的变化，所有这些都将减少昆虫的病媒能力。如果这种影响足够大，杀虫剂抗药性对疾病管理的影响可能不像以前认为的那样有害。然而，在其他情况下，杀虫剂抗药性可能产生相反的效果，增加昆虫的传病能力，这可能导致疾病传播的急剧增加，甚至比没有杀虫剂的情况下更高的流行率。无论哪种方式--而且可能没有简单的普遍性--杀虫剂抗性进化对疾病生态的后果值得额外关注。
Many of the most dangerous human diseases are transmitted by insect vectors. After decades of repeated insecticide use, all of these vector species have demonstrated the capacity to evolve resistance to insecticides. Insecticide resistance is generally considered to undermine control of vector-transmitted diseases because it increases the number of vectors that survive the insecticide treatment. Disease control failure, however, need not follow from vector control failure. Here, we review evidence that insecticide resistance may have an impact on the quality of vectors and, specifically, on three key determinants of parasite transmission: vector longevity, competence, and behaviour. We argue that, in some instances, insecticide resistance is likely to result in a decrease in vector longevity, a decrease in infectiousness, or in a change in behaviour, all of which will reduce the vectorial capacity of the insect. If this effect is sufficiently large, the impact of insecticide resistance on disease management may not be as detrimental as previously thought. In other instances, however, insecticide resistance may have the opposite effect, increasing the insect's vectorial capacity, which may lead to a dramatic increase in the transmission of the disease and even to a higher prevalence than in the absence of insecticides. Either way—and there may be no simple generality—the consequence of the evolution of insecticide resistance for disease ecology deserves additional attention.
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DOI：
10.1017/s001667230100547x
发表时间：
2002-02-01
期刊：
GENETICAL RESEARCH
影响因子：
--
作者：
Berticat, C;Boquien, G;Chevillon, C
通讯作者：
Chevillon, C
影响因子：
3.4
作者：
Chongsatja, Phattara-orn;Bourchookarn, Apichai;Krittanai, Chartchai
通讯作者：
Krittanai, Chartchai
影响因子：
2.1
作者：
BALL, GH;CHAO, J
通讯作者：
CHAO, J
影响因子：
3.3
作者：
Agnew, P;Berticat, C;Michalakis, Y
通讯作者：
Michalakis, Y
影响因子：
2.1
作者：
Chevillon, C;Bernard, C;Pasteur, N
通讯作者：
Pasteur, N