Finding their way: themes in germ cell migration.

Finding their way: themes in germ cell migration.
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DOI:
10.1016/j.ceb.2016.07.007
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发表时间:
2016-10
影响因子:
7.5
通讯作者:
Lehmann, Ruth
Lehmann, Ruth
中科院分区:
生物学2区
文献类型:
--
作者:
Barton, Lacy J.;LeBlanc, Michelle G.;Lehmann, Ruth

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胚胎生殖细胞迁移是生殖细胞生命周期的重要组成部分。生殖细胞从起源地易位到发育中的体细胞性腺涉及几个过程,包括与底层组织的被动运动、跨上皮迁移、细胞粘附动力学、环境引导线索的建立和维持定向迁移的能力。本综述将讨论生殖细胞如何在已建立的模型生物体中实现这些壮举,重点关注跨物种的最新发现和主题。
Embryonic germ cell migration is a vital component of the germline lifecycle. The translocation of germ cells from the place of origin to the developing somatic gonad involves several processes including passive movements with underlying tissues, transepithelial migration, cell adhesion dynamics, the establishment of environmental guidance cues and the ability to sustain directed migration. How germ cells accomplish these feats in established model organisms will be discussed in this review, with a focus on recent discoveries and themes conserved across species.
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