Prevalence and Risk Factors of Genital Human Papillomavirus Infections among Women in Lagos, Nigeria.
Prevalence and Risk Factors of Genital Human Papillomavirus Infections among Women in Lagos, Nigeria.
复制标题
DOI：
10.3390/tropicalmed7110386
复制
发表时间：
2022-11-18
影响因子：
2.9
通讯作者：
Agbede OO
中科院分区：
文献类型：
--
作者：
Ashaka OS;Omoare AA;James AB;Adeyemi OO;Oladiji F;Adeniji KA;Okunade KS;Agbede OO
尽管有报告称非洲妇女的 HPV 患病率很高，但全世界 HPV 患病率仍存在地区差异。由于生殖器 HPV 患病率的数据有限，因此有必要进行这项研究，目的是确定尼日利亚拉各斯妇女中生殖器 HPV 的患病率及相关危险因素。经 165 名女性同意，使用宫颈刷收集脱落的宫颈细胞。使用两组共有引物（MY09/11 和 GP5+/6+）通过巢式 PCR 提取和扩增病毒 DNA。使用无条件逻辑回归模型来确定 HPV 阳性的预测因素。所有女性中 HPV 患病率为 81.82%，细胞学检查正常女性中 HPV 患病率为 87.59%。有性传播感染病史的女性感染 HPV 的风险显着增加（比值比 (OR) 3.94；95% 置信区间 (CI)：1.51–10.25，p = 0.005），而使用避孕套的女性感染 HPV 的风险显着降低（比值比 (OR) 3.94；95% 置信区间 (CI)：0.18–0.91，p = 0.03）。观察到的 HPV 患病率表明该病毒在尼日利亚拉各斯的传播有所增加。因此，需要提高公众意识并实施早期检测、治疗和疫苗接种，以防止尼日利亚拉各斯宫颈癌病例的增加。
Regional variations exist in HPV prevalence worldwide despite reports of high prevalence rates among African women. Limited data on genital HPV prevalence necessitated this study with the aim of determining the prevalence of genital HPV and associated risk factors among women in Lagos, Nigeria. Exfoliated cervical cells were collected with consent from 165 women using a cervical brush. Viral DNA was extracted and amplified by nested PCR using two sets of consensus primers (MY09/11 and GP5+/6+). An unconditional logistic regression model was used to identify predictors of HPV positivity. The HPV prevalence was 81.82% in all women and 87.59% in women with normal cytology. The risk of HPV infection was significantly increased among women who had a history of STI (odds ratio (OR) 3.94; 95% confidence interval (CI): 1.51–10.25, p = 0.005) while there was a significantly reduced risk of HPV infection among those who used condoms (odds ratio (OR) 3.94; 95% confidence interval (CI): 0.18–0.91, p = 0.03). The HPV prevalence observed shows an increased transmission of the virus in Lagos, Nigeria. Therefore, there is a need for intense public awareness and the implementation of early detection tests, treatment, and vaccination to prevent an increase in cervical cancer cases in Lagos, Nigeria.
登录
查看更多内容
影响因子：
1.9
作者：
Hammou, Rahma Ait;Benhessou, Mustapha;Ennaji, Moulay Mustapha
通讯作者：
Ennaji, Moulay Mustapha
影响因子：
3.7
作者：
Nejo, Yewande T.;Olaleye, David O.;Odaibo, Georgina N.
通讯作者：
Odaibo, Georgina N.
影响因子：
6.4
作者：
Gage, Julia C.;Ajenifuja, Kayode O.;Schiffman, Mark
通讯作者：
Schiffman, Mark
影响因子：
7.2
作者：
Lindau, Stacy Tessler;Drum, Melinda L.;Jordan, Jeanne A.
通讯作者：
Jordan, Jeanne A.
影响因子：
12.7
作者：
Blossom, D. B.;Beigi, R. H.;Salata, R. A.
通讯作者：
Salata, R. A.