Dog size and patterns of disease history across the canine age spectrum: Results from the Dog Aging Project.
Dog size and patterns of disease history across the canine age spectrum: Results from the Dog Aging Project.
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DOI：
10.1371/journal.pone.0295840
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发表时间：
2024
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
狗的年龄与许多疾病的风险有关，而犬的大小是造成这种风险的主要因素。然而，尺寸图案很复杂。虽然小型犬往往寿命更长，但一些疾病在小型犬中更为普遍。在这项研究中，我们试图量化疾病史模式在狗的体型、狗年龄及其相互作用范围内的变化。利用参加狗衰老项目的大量伴侣犬的主人报告的疾病史数据，我们研究了以体重测量的体型与所报告疾病的终生患病率及其不同疾病类别的年龄模式之间的关系。我们发现狗的体型与皮肤、骨骼/骨科、胃肠道、耳/鼻/喉、癌症/肿瘤、脑/神经系统、内分泌和传染病的终生患病率之间存在显着的正相关关系。同样，狗的体型与眼部、心脏、肝脏/胰腺和呼吸道疾病类别的终生患病率呈负相关。肾脏/泌尿系统疾病的患病率并不因体型大小而异。我们还发现，对于许多疾病，包括眼科、心脏、骨科、耳/鼻/喉和癌症，年龄和终生疾病患病率之间的关联因狗的大小而异。控制性别、纯种与混种状态以及地理区域对我们研究的所有疾病类别几乎没有什么影响。我们的结果与大多数疾病类别的大型犬的寿命缩短相一致，并提出了进一步检查的潜在途径。
Age in dogs is associated with the risk of many diseases, and canine size is a major factor in that risk. However, the size patterns are complex. While small size dogs tend to live longer, some diseases are more prevalent among small dogs. In this study we seek to quantify how the pattern of disease history varies across the spectrum of dog size, dog age, and their interaction. Utilizing owner-reported data on disease history from a substantial number of companion dogs enrolled in the Dog Aging Project, we investigate how body size, as measured by weight, associates with the lifetime prevalence of a reported condition and its pattern across age for various disease categories. We found significant positive associations between dog size and the lifetime prevalence of skin, bone/orthopedic, gastrointestinal, ear/nose/throat, cancer/tumor, brain/neurologic, endocrine, and infectious diseases. Similarly, dog size was negatively associated with lifetime prevalence of ocular, cardiac, liver/pancreas, and respiratory disease categories. Kidney/urinary disease prevalence did not vary by size. We also found that the association between age and lifetime disease prevalence varied by dog size for many conditions including ocular, cardiac, orthopedic, ear/nose/throat, and cancer. Controlling for sex, purebred vs. mixed-breed status, and geographic region made little difference in all disease categories we studied. Our results align with the reduced lifespan in larger dogs for most of the disease categories and suggest potential avenues for further examination.
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DOI：
10.1002/jez.b.21116
发表时间：
2007-03-15
影响因子：
2.2
作者：
Galis, Frietson;Van Der Sluijs, Inke;Nussbaumer, Marc
通讯作者：
Nussbaumer, Marc
影响因子：
4.6
作者：
Anderson, Katharine L.;O'Neill, Dan G.;Collins, Lisa M.
通讯作者：
Collins, Lisa M.
影响因子：
5.4
作者：
Creevy, Kate E.;Austad, Steven N.;Promislow, Daniel E. L.
通讯作者：
Promislow, Daniel E. L.
影响因子：
2.6
作者：
Fall, Tove;Hamlin, Helene Hansson;Egenvall, Agneta
通讯作者：
Egenvall, Agneta
影响因子：
1.4
作者：
Cosgrove, Sallie B.;Cleaver, Dawn M.;Stegemann, Michael R.
通讯作者：
Stegemann, Michael R.