Aging, Osteocytes, and Mechanotransduction.
Aging, Osteocytes, and Mechanotransduction.
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DOI：
10.1007/s11914-017-0402-z
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发表时间：
2017-10
影响因子：
4.3
通讯作者：
van Lenthe GH
中科院分区：
文献类型：
--
作者：
Hemmatian H;Bakker AD;Klein-Nulend J;van Lenthe GH
骨能够通过由机械敏感性骨细胞控制的骨重建过程使其结构适应机械信号。随着年龄的增长，骨重建的不平衡导致骨质疏松症。在这篇综述中，我们假设骨陷窝形态学的变化是随着年龄的增长骨对机械负荷的机械反应性降低的基础。一些研究报道了骨细胞的形状和它们的陷窝随着年龄的增长而发生相当大的变化。由于骨细胞可以通过其细胞体直接感受基质应变，骨细胞形态的变化可能会导致骨细胞力学敏感性的变化。因此，骨细胞的负荷适应性反应可能会随着年龄的增长而变化，即使机械负荷保持不变。虽然缺乏大量的定量数据，但有证据表明，随着年龄的增长，骨细胞陷窝变得越来越小，越来越球形。未来的专门研究可能会揭示这些变化是否会影响骨细胞的机械感觉和随后的生物反应，以及这是否是与年龄相关的骨丢失的途径之一。
The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. Several studies have reported considerable variations in the shape of osteocytes and their lacunae with aging. Since osteocytes can sense matrix strain directly via their cell bodies, the variations in osteocyte morphology may cause changes in osteocyte mechanosensitivity. As a consequence, the load-adaptive response of osteocytes may change with aging, even when mechanical loading would remain unchanged. Though extensive quantitative data is lacking, evidence exists that the osteocyte lacunae are becoming smaller and more spherical with aging. Future dedicated studies might reveal whether these changes would affect osteocyte mechanosensation and the subsequent biological response, and whether this is (one of) the pathways involved in age-related bone loss.
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影响因子：
2.4
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通讯作者：
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