Cross system autonomic balance and regulation: Associations with depression and anxiety symptoms.
Cross system autonomic balance and regulation: Associations with depression and anxiety symptoms.
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DOI：
10.1111/psyp.13636
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发表时间：
2020-10
期刊：
影响因子：
3.7
通讯作者：
Bylsma LM
中科院分区：
文献类型：
--
作者：
Stone LB;McCormack CC;Bylsma LM
自主神经系统（ANS）已被证明可用于识别与常见精神病理学（包括抑郁症和焦虑症）相关的情绪处理改变。迄今为止，大多数ANS研究都有一些局限性。大多数研究分别检查了副交感神经和交感神经分支，需要推断另一个分支的活动。这是有问题的，因为每个分支可以独立地起作用。心脏自主神经平衡（CAB）和心脏自主神经调节（CAR）等综合指标检查呼吸性窦性心律失常（RSA）和射血前期（PEP）之间的相对输入，应提供更全面的自主神经功能的措施，从而更强的预测精神病理学。然而，交感神经分支由多种神经递质系统驱动，因此PEP不一定反映总体SNS唤醒。我们提出了两个新的指标评估ANS功能与精神病理学：副交感神经对心脏控制（RSA）相对于交感神经对外分泌系统（皮肤电活动，EDA）的影响，我们称之为跨系统自主平衡（CSAB）和调节（CSAR）。85名女性（18-37岁）完成了副交感神经（RSA）和交感神经指数（PEP，EDA）的基线生理评估，沿着自我报告的抑郁和焦虑症状。较低的CSAB，表明胆碱能神经传递驱动的交感神经优势，与较高的抑郁和焦虑症状。较低的CAB表明β-肾上腺素能神经传递驱动的交感神经支配与抑郁症状特别相关。CSAB是一个比RSA更强大的索引。结果支持的效用，评估多个复合ANS指数，以确定与内化障碍相关的情绪调节的改变的生理基板。
The autonomic nervous system (ANS) has demonstrated utility for identifying alterations in emotion processing associated with common psychopathology, including depression and anxiety. To date though the majority of this ANS research has several limitations. Most studies have examined parasympathetic and sympathetic branches separately, requiring activity in the other branch be inferred. This is problematic as each branch may function independently. Composite indices such as cardiac autonomic balance (CAB) and cardiac autonomic regulation (CAR) which examine the relative input between respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) should provide more comprehensive measures of autonomic functioning and thus stronger predictors of psychopathology. However, the sympathetic branch is driven by multiple neurotransmitter systems, thus PEP does not necessarily reflect overall SNS arousal. We propose two new metrics for assessing ANS functioning associated with psychopathology: parasympathetic effects on cardiac control (RSA) relative to sympathetic effects on the eccrine system (electrodermal activity, EDA), which we term cross-system autonomic balance (CSAB) and regulation (CSAR). Eighty-five women (18–37) completed a baseline physiological assessment with parasympathetic (RSA) and sympathetic indices (PEP, EDA), along with self-reported depressive and anxiety symptoms. Lower CSAB, indicating sympathetic dominance driven by cholinergic neurotransmission, was associated with higher depressive and anxiety symptoms. Lower CAB indicating sympathetic dominance driven by beta-adrenergic neurotransmission was associated specifically with depressive symptoms. CSAB was a more robust index than RSA. Results support the utility of assessing multiple composite ANS indices for identifying physiological substrates of alterations in emotion regulation associated with internalizing disorders.
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DOI：
10.1111/j.1540-5834.2009.00501.x
发表时间：
2009
影响因子：
9.5
作者：
El-Sheikh M;Kouros CD;Erath S;Cummings EM;Keller P;Staton L
通讯作者：
Staton L
影响因子：
5.9
作者：
Beauchaine, Theodore P
通讯作者：
Beauchaine, Theodore P
影响因子：
3.7
作者：
Brush, Christopher J.;Olson, Ryan L.;Alderman, Brandon L.
通讯作者：
Alderman, Brandon L.
焦虑症与心率变异性降低有关：荟萃分析。
影响因子：
4.7
作者：
Chalmers JA;Quintana DS;Abbott MJ;Kemp AH
通讯作者：
Kemp AH
影响因子：
10.3
作者：
Amstadter, Ananda
通讯作者：
Amstadter, Ananda