Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder.
Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder.
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DOI：
10.1111/adb.12421
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发表时间：
2017-09
影响因子：
3.4
通讯作者：
Momenan R
中科院分区：
文献类型：
--
作者：
Grodin EN;Momenan R
长期饮酒对大脑形态测量有广泛影响。酒精依赖者经常被诊断出患有共病物质使用障碍。单独依赖酒精的人和依赖酒精和其他物质的人，大脑形态测量的变化可能不同。我们检测了37名单纯酒精依赖者(ADO)、37名多物质使用障碍(PS)患者和37名健康对照组(HC)的大脑皮质下体积。参与者接受了结构磁共振扫描，并使用基于模型的分割工具测量了14个皮质下区域(双侧丘脑、尾状核、壳核、苍白球、海马体、杏仁核和伏隔核)的体积。与HC相比，ADO在双侧海马、右侧伏隔核和右侧丘脑的体积较小。与HC相比，PS只有双侧丘脑的体积减小。与ADO相比，PS的右侧尾状核较大。仅在ADO组，皮质下体积与饮酒措施呈负相关。这项研究证实了酒精依赖和皮质下脑体积减少之间的联系。这也表明，使用多物质和酒精使用相互作用，产生有限的皮质下体积减少和至少一个区域的皮质下体积增加。这些发现表明，额外的物质使用可能会通过炎症来掩盖损害，或者可能以一种保护性的方式发挥作用，保护皮质下区域免受酒精诱导的损害。
Chronic alcohol use has widespread effects on brain morphometry. Alcohol dependent individuals are often diagnosed with comorbid substance use disorders. Alterations in brain morphometry may be different in individuals that are dependent on alcohol alone and individuals dependent on alcohol and other substances. We examined subcortical brain volumes in 37 individuals with alcohol dependence only (ADO), 37 individuals with polysubstance use disorder (PS), and 37 healthy control participants (HC). Participants underwent a structural MR scan and a model-based segmentation tool was used to measure the volume of 14 subcortical regions (bilateral thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, and nucleus accumbens). Compared to HC, ADO had smaller volume in the bilateral hippocampus, right nucleus accumbens, and right thalamus. PS only had volume reductions in the bilateral thalamus compared to HC. PS had a larger right caudate compared to ADO. Subcortical volume was negatively associated with drinking measures only in the ADO group. This study confirms the association between alcohol dependence and reductions in subcortical brain volume. It also suggests that polysubstance use interacts with alcohol use to produce limited subcortical volume reduction and at least one region of subcortical volume increase. These findings indicate that additional substance use may mask damage through inflammation or may function in a protective manner, shielding subcortical regions from alcohol-induced damage.
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影响因子：
4.2
作者：
Fein, George;Fein, David
通讯作者：
Fein, David
影响因子：
11
作者：
HARPER, C;CORBETT, D
通讯作者：
CORBETT, D
DOI：
10.1111/j.1530-0277.2009.01108.x
发表时间：
2010-03-01
影响因子：
3.2
作者：
Green, Alisa;Garrick, Therese;Harper, Clive
通讯作者：
Harper, Clive
DOI：
10.1016/j.pnpbp.2014.05.003
发表时间：
2014-10-03
影响因子：
5.6
作者：
Geil, Chelsea R.;Hayes, Dayna M.;McClain, Justin A.;Liput, Daniel J.;Marshall, S. Alex;Chen, Kevin Y.;Nixon, Kimberly
通讯作者：
Nixon, Kimberly
影响因子：
5.7
作者：
Gozzi A;Agosta F;Massi M;Ciccocioppo R;Bifone A
通讯作者：
Bifone A