Contextual, but not auditory, fear conditioning is disrupted by neurotoxic selective lesion of the basal nucleus of amygdala in rats
Contextual, but not auditory, fear conditioning is disrupted by neurotoxic selective lesion of the basal nucleus of amygdala in rats
复制标题
大鼠杏仁核基底核的神经毒性选择性损伤破坏了情境而非听觉的恐惧条件反射
DOI：
10.1016/j.nlm.2009.09.007
复制
发表时间：
2010
影响因子：
2.7
通讯作者：
G. Xavier
中科院分区：
文献类型：
--
作者：
Barbara K. A. Onishi;G. Xavier
基底外侧杏仁核复合体(BLA)参与语境和听觉恐惧条件反射的获得。然而，BLA不是一个单一的结构，而是由一组核组成，包括外侧核(LA)、基底核(BA)和副基底核(AB)。虽然人们一致认为LA在听觉恐惧条件反射中起着关键作用，但对于BA在恐惧条件反射中的参与存在争议。霍奇学和神经生理学的研究结果表明，这些核团中的每一个都并行地处理不同的信息；BA处理多模式或语境表征，LA处理单峰表征或元素表征。因此，似乎有可能假设BA是背景恐惧条件反射所必需的，但不是听觉条件反射。这一假说在Wistar大鼠身上进行了评估，这些大鼠接受了限制在BA上的多部位ibotenate诱导的损伤，然后暴露于同时进行的语境和听觉恐惧条件反射训练，然后分别进行语境和听觉条件反射测试。与电解性损伤和利多卡因灭活不同，这种手术入路不会干扰起源于其他脑区的通路纤维，限制了对目标核的损害。与假操作对照组相比，选择性损害BA的大鼠在任务的语境部分表现出干扰，但在听觉部分没有表现出干扰。因此，尽管BA似乎是背景恐惧条件反射所必需的，但它对听觉-美国联想和表达冻结反应都不是至关重要的。
The basolateral amygdala complex (BLA) is involved in acquisition of contextual and auditory fear conditioning. However, the BLA is not a single structure but comprises a group of nuclei, including the lateral (LA), basal (BA) and accessory basal (AB) nuclei. While it is consensual that the LA is critical for auditory fear conditioning, there is controversy on the participation of the BA in fear conditioning. Hodological and neurophysiological findings suggest that each of these nuclei processes distinct information in parallel; the BA would deal with polymodal or contextual representations, and the LA would process unimodal or elemental representations. Thus, it seems plausible to hypothesize that the BA is required for contextual, but not auditory, fear conditioning. This hypothesis was evaluated in Wistar rats submitted to multiple-site ibotenate-induced damage restricted to the BA and then exposed to a concurrent contextual and auditory fear conditioning training followed by separated contextual and auditory conditioning testing. Differing from electrolytic lesion and lidocaine inactivation, this surgical approach does not disturb fibers of passage originating in other brain areas, restricting damage to the aimed nucleus. Relative to the sham-operated controls, rats with selective damage to the BA exhibited disruption of performance in the contextual, but not the auditory, component of the task. Thus, while the BA seems required for contextual fear conditioning, it is not critical for both an auditory-US association, nor for the expression of the freezing response.
登录
查看更多内容
NMDA 过程介导海马损伤引起的情境恐惧调节的顺行性遗忘：通过情境预暴露对遗忘进行免疫。
影响因子：
1.9
作者：
Young,SL;Bohenek,DL;Fanselow,MS
通讯作者：
Fanselow,MS
大鼠基底外侧杏仁核兴奋性毒性损伤后条件性恐惧的逆行消除：缺乏时间梯度。
影响因子：
1.9
作者：
Maren,S;Aharonov,G;Fanselow,MS
通讯作者：
Fanselow,MS
影响因子：
1.9
作者：
PHILLIPS, RG;LEDOUX, JE
通讯作者：
LEDOUX, JE
影响因子：
2
作者：
Goosens, KA;Maren, S
通讯作者：
Maren, S
杏仁核内注射 N-甲基-D-天冬氨酸受体拮抗剂 AP5 可阻止对听觉条件刺激的恐惧增强惊吓的获得，但不会阻止其表达。
影响因子：
1.9
作者：
Campeau,S;Miserendino,MJ;Davis,M
通讯作者：
Davis,M